| Gene Symbol |
ATP5A1
|
| Entrez Gene |
282578
|
| Alt Symbol |
-
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
|
| Other Description |
ATP synthase alpha subunit|ATP synthase subunit alpha, mitochondrial
|
| Swissprots |
P19483 Q1JQC4 P19482 P05629
|
| Accessions |
CAA45865 DAA15776 P19483 BC116059 AAI16060 M19680 AAA30399 M22465 AAB59266 XM_005224109 XP_005224166 NM_174684 NP_777109
|
| Function |
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion inner membrane {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Colocalizes with HRG on the cell surface of T-cells. {ECO:0000250}.
|
| Tissue Specificity |
Heart and liver.
|
| Top Pathways |
Alzheimer's disease, Huntington's disease, Oxidative phosphorylation
|