| Gene Symbol |
GOT1
|
| Entrez Gene |
100340431
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
glutamic-oxaloacetic transaminase 1, soluble
|
| Other Description |
aspartate aminotransferase 1|glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
|
| Swissprots |
P12343
|
| Accessions |
GBCN01004027 XM_002718630 XP_002718676
|
| Function |
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Top Pathways |
Cysteine and methionine metabolism, Tyrosine metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism, Biosynthesis of amino acids
|