| Gene Symbol |
SLC29A3
|
| Entrez Gene |
55315
|
| Alt Symbol |
ENT3, HCLAP, HJCD, PHID
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 29 (equilibrative nucleoside transporter), member 3
|
| Other Description |
equilibrative nucleoside transporter 3|solute carrier family 29 (nucleoside transporters), member 3
|
| Swissprots |
B4E2Z9 B7ZA37 Q8IVZ0 Q0VAM9 Q5T465 Q9BWI2 Q7RTT8 Q9NUS9 Q9BZD2 B2RB50
|
| Accessions |
CAH05407 DAA00364 EAW54423 EAW54424 EAW54425 Q9BZD2 AF326987 AAK00958 AK002022 BAA92041 AK304503 BAG65311 AK314497 BAG37097 AK316152 BAH14523 AX775915 CAE11657 AX775917 CAE11658 AX775919 CAE11659 AX775921 CAE11660 AY288928 AAP41133 AY358686 AAQ89049 BC000223 AAH00223 BC041575 AAH41575 BC050589 BC063019 BC120996 AAI20997 BC120997 AAI20998 DC319920 XM_006717910 XP_006717973 NM_001174098 NP_001167569 NM_018344 NP_060814 NR_033413 NR_033414
|
| Function |
Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine. {ECO:0000269|PubMed:15701636}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface.
|
| Tissue Specificity |
Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart. {ECO:0000269|PubMed:15701636}.
|