Gene Symbol | phoP |
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Entrez Gene | 945697 |
Alt Symbol | ECK1116, JW1116 |
Species | Escherichia coli |
Gene Type | protein-coding |
Description | response regulator in two-component regulatory system with PhoQ |
Other Description | - |
Swissprots | P23836 |
Accessions | AAC74214 NP_415648 |
Function | Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. {ECO:0000250, ECO:0000269|PubMed:10464230}. |
Subcellular Location | Cytoplasm {ECO:0000305}. |
Top Pathways | Two-component system, Cationic antimicrobial peptide (CAMP) resistance |
Recombinant Escherichia coli Transcriptional regulatory protein phoP(phoP) - CSB-YP326097ENV CSB-EP326097ENV CSB-BP326097ENV CSB-MP326097ENV from Cusabio
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E. coli phoP protein - orb54763 from Biorbyt
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E. coli phoP protein - orb54594 from Biorbyt
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E. coli phoP protein - orb54595 from Biorbyt
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PHOP Recombinant Protein (Escherichia coli) (OPCA05090) - OPCA05090 from Aviva Systems Biology
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PHOP Recombinant Protein (Escherichia coli) (OPCA05091) - OPCA05091 from Aviva Systems Biology
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PHOP Recombinant Protein (Escherichia coli) (OPCA05200) - OPCA05200 from Aviva Systems Biology
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PHOP Recombinant Protein (Escherichia coli) (OPCA05450) - OPCA05450 from Aviva Systems Biology
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E. coli PHOP protein - orb418873 from Biorbyt
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E. coli PHOP protein - orb418872 from Biorbyt
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E. coli PHOP protein - orb418917 from Biorbyt
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Recombinant Escherichia coli PHOP Protein (1-223 aa), His-Myc-tagged - PHOP-2165E from Creative Biomart
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Recombinant Escherichia coli PHOP Protein (1-223 aa), His-Myc-tagged - PHOP-2203E from Creative Biomart
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