| Gene Symbol | XRN1 |
|---|---|
| Entrez Gene | 54464 |
| Alt Symbol | SEP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 5'-3' exoribonuclease 1 |
| Other Description | strand-exchange protein 1 homolog |
| Swissprots | Q8N8U4 Q86WS7 Q4G0S3 Q9UF39 Q6AI24 Q8IZH2 Q6MZS8 Q68D88 |
| Accessions | CBM42916 CBV35649 EAW78971 EAW78972 EAW78973 Q8IZH2 AK096177 BAC04718 AK123897 BAG53979 AK304312 BAG65165 AL117516 AL133623 CAB63749 AY137776 AAN11306 BC039314 AAH39314 BC048104 AAH48104 BC078146 BC141555 AAI41556 BG197321 BX640905 CAE45950 CR627160 CR627396 CAH10490 CR749518 CAH18332 XM_006713673 XP_006713736 XM_011512919 XP_011511221 XM_011512920 XP_011511222 XM_011512921 XP_011511223 XM_011512922 XP_011511224 XM_011512923 XP_011511225 NM_001282857 NP_001269786 NM_001282859 NP_001269788 NM_019001 NP_061874 NM_001042604 |
| Function | Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). {ECO:0000250, ECO:0000269|PubMed:18172165}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:14580940, ECO:0000269|PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane. |
| Tissue Specificity | Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. {ECO:0000269|PubMed:12426100}. |
| Top Pathways | RNA degradation, Ribosome biogenesis in eukaryotes |
XRN1 CRISPR/Cas9 KO Plasmid (h) - sc-401910 from Santa Cruz Biotechnology
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XRN1 HDR Plasmid (h) - sc-401910-HDR from Santa Cruz Biotechnology
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XRN1 Double Nickase Plasmid (h) - sc-401910-NIC from Santa Cruz Biotechnology
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XRN1 Double Nickase Plasmid (h2) - sc-401910-NIC-2 from Santa Cruz Biotechnology
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XRN1 CRISPR Activation Plasmid (h) - sc-401910-ACT from Santa Cruz Biotechnology
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XRN1 CRISPR Activation Plasmid (h2) - sc-401910-ACT-2 from Santa Cruz Biotechnology
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XRN1 Lentiviral Activation Particles (h) - sc-401910-LAC from Santa Cruz Biotechnology
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XRN1 Lentiviral Activation Particles (h2) - sc-401910-LAC-2 from Santa Cruz Biotechnology
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XRN1 siRNA (h) - sc-61811 from Santa Cruz Biotechnology
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XRN1 shRNA Plasmid (h) - sc-61811-SH from Santa Cruz Biotechnology
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XRN1 shRNA (h) Lentiviral Particles - sc-61811-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU043071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22988 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22988 from Sigma-Aldrich
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XRN1 siRNA (Human) - CRJ0072 from Cohesion Biosciences
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XRN1 - MBS8238722 from MyBioSource
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shRNA set against Human XRN1 (NM_019001.3) - SHH448156 from Creative biogene
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shRNA set against Human XRN1(NM_001042604.1) - SHL138982 from Creative biogene
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shRNA set against Human XRN1(NM_019001.3) - SHL139194 from Creative biogene
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shRNA set against Human XRN1(NM_001042604.1) - SHL139212 from Creative biogene
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XRN1 shRNA Plasmid (Human) - CHJ0072 from Cohesion Biosciences
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XRN1 miRNA 3'UTR clone - MiUTR1H-11324 from Creative biogene
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XRN1 miRNA 3'UTR clone - MiUTR1H-11325 from Creative biogene
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