Gene Symbol | PIGL |
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Entrez Gene | 9487 |
Alt Symbol | CHIME |
Species | Human |
Gene Type | protein-coding |
Description | phosphatidylinositol glycan anchor biosynthesis, class L |
Other Description | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase|N-acetylglucosaminylphosphatidylinositol deacetylase|PIG-L|phosphatidylinositol glycan, class L|phosphatidylinositol-glycan biosynthesis class L protein |
Swissprots | B4DYN4 Q9Y2B2 A8KA67 |
Accessions | EAX04497 EAX04498 Q9Y2B2 AB017165 BAA74775 AI888858 AK023469 AK292932 BAF85621 AK296120 BAG58868 AK302523 BAG63796 BC068197 AAH68197 BX404762 HQ447574 ADQ32060 XM_011524080 XP_011522382 XR_243571 XR_429826 NM_004278 NP_004269 |
Function | Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
PIG-L CRISPR/Cas9 KO Plasmid (h) - sc-411285 from Santa Cruz Biotechnology
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PIG-L HDR Plasmid (h) - sc-411285-HDR from Santa Cruz Biotechnology
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PIG-L Double Nickase Plasmid (h) - sc-411285-NIC from Santa Cruz Biotechnology
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PIG-L Double Nickase Plasmid (h2) - sc-411285-NIC-2 from Santa Cruz Biotechnology
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PIG-L CRISPR Activation Plasmid (h) - sc-411285-ACT from Santa Cruz Biotechnology
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PIG-L CRISPR Activation Plasmid (h2) - sc-411285-ACT-2 from Santa Cruz Biotechnology
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PIG-L Lentiviral Activation Particles (h) - sc-411285-LAC from Santa Cruz Biotechnology
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PIG-L Lentiviral Activation Particles (h2) - sc-411285-LAC-2 from Santa Cruz Biotechnology
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PIG-L siRNA (h) - sc-93912 from Santa Cruz Biotechnology
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PIG-L shRNA Plasmid (h) - sc-93912-SH from Santa Cruz Biotechnology
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PIG-L shRNA (h) Lentiviral Particles - sc-93912-V from Santa Cruz Biotechnology
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PIGL RNAi - H00009487-R01 from Novus Biologicals
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MISSION® esiRNA - EHU129281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16789 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16789 from Sigma-Aldrich
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PIGL siRNA (Human) - CRH6299 from Cohesion Biosciences
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shRNA set against Human PIGL (NM_004278.3) - SHH375432 from Creative biogene
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shRNA set against Human PIGL(NM_004278.3) - SHR113908 from Creative biogene
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Human PIGL siRNA - orb266801 from Biorbyt
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PIGL shRNA Plasmid (Human) - CHH6299 from Cohesion Biosciences
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PIGL miRNA 3'UTR clone - MiUTR1H-07893 from Creative biogene
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