SWAP70

Gene Symbol	SWAP70
Entrez Gene	23075
Alt Symbol	HSPC321, SWAP-70
Species	Human
Gene Type	protein-coding
Description	SWAP switching B-cell complex 70kDa subunit
Other Description	switch-associated protein 70
Swissprots	Q7LCY6 Q9P061 Q9P0Z8 D3DQV1 O75135 Q9UH65
Accessions	EAW68582 EAW68583 EAW68584 EAW68585 Q9UH65 AB014540 BAA31615 AF134894 AAF61403 AF161439 AAF28999 AF210818 AAF24486 AI693686 AK027131 AK096859 BAG53381 AK304104 BAG65007 AL110154 BC000134 BC000616 AAH00616 DA413747 XM_005252830 XP_005252887 NM_001297714 NP_001284643 NM_015055 NP_055870
Function	Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
Tissue Specificity	Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SWAP-70 (F-3) - sc-390431 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

SWAP-70 (E-16) - sc-10883 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SWAP-70 (H-17) - sc-10882 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SWAP-70 (H-131) - sc-292840 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

SWAP-70 (Q-28) - sc-81991 from Santa Cruz Biotechnology Prices $295.00 Sizes 50 µg/0.5 ml Host Mouse Clonality Monoclonal

SWAP-70 (Z-24) - sc-130887 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-SWAP70 antibody - ab89532 from Abcam Prices $370.00 Sizes 200 µl Host Mouse Clonality Monoclonal

Anti-SWAP70 antibody - ab89605 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-SWAP70 antibody - ab2511 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SWAP70 antibody - ab47084 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SWAP70 antibody - ab150325 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody (clone 434CT16.5.5, APC) - LS-C250431 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 434CT16.5.5

Anti-SWAP70 Antibody (aa300-350) - LS-C19341 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody (clone 434CT16.5.5, AP) - LS-C250432 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 434CT16.5.5

Anti-SWAP70 Antibody (aa51-100) - LS-C80858 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody (clone 434CT16.5.5, Biotin) - LS-C250433 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 434CT16.5.5

Anti-SWAP70 Antibody (clone 434CT16.5.5, FITC) - LS-C250434 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 434CT16.5.5

Anti-SWAP70 Antibody (clone 434CT16.5.5, Azide-free, HRP) - LS-C250436 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 434CT16.5.5

Anti-SWAP70 Antibody (clone 434CT16.5.5, PE) - LS-C250437 from LifeSpan Bioscience Prices $545.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 434CT16.5.5

Anti-SWAP70 Antibody (Internal, APC) - LS-C283242 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody (Internal, Biotin) - LS-C283243 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody (C-Terminus) - LS-C55544 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SWAP70 Antibody (Internal, Azide-free, HRP) - LS-C283244 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody (Internal, FITC) - LS-C283245 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SWAP70 Antibody - LS-C157116 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Mouse Clonality Monoclonal

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