Gene Symbol | MARCH5 |
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Entrez Gene | 54708 |
Alt Symbol | MARCH-V, MITOL, RNF153 |
Species | Human |
Gene Type | protein-coding |
Description | membrane-associated ring finger (C3HC4) 5 |
Other Description | E3 ubiquitin-protein ligase MARCH5|membrane-associated RING finger protein 5|membrane-associated RING-CH protein V|mitochondrial ubiquitin ligase|ring finger protein 153 |
Swissprots | Q9NX47 |
Accessions | EAW50094 EAW50095 EAW50096 Q9NX47 AB191202 BAF02285 AK000452 BAA91173 AK294799 BAG57919 AK309175 BC015480 AAH15480 BE393612 JF432871 ADZ16088 XM_011539886 XP_011538188 NM_017824 NP_060294 |
Function | Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269|PubMed:16874301, ECO:0000269|PubMed:17606867, ECO:0000269|PubMed:19741096, ECO:0000269|PubMed:20103533}. |
Subcellular Location | Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:16874301}. |
Tissue Specificity | Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle. {ECO:0000269|PubMed:16874301}. |
Human MARCH5 full length protein - ab132865 from Abcam
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Human MARCH5 peptide - ab87426 from Abcam
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Human MARCH5 protein fragment - ab162820 from Abcam
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MARCH5 Antibody Blocking Peptide - LS-E7927 from LifeSpan Bioscience
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MARCH5 Blocking Peptide - LS-E15906 from LifeSpan Bioscience
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MARCH5 Antibody Blocking Peptide - LS-E15907 from LifeSpan Bioscience
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Recombinant Human MARCH5 Protein - H00054708-Q01 from Novus Biologicals
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Recombinant Human MARCH5 Protein - H00054708-P01 from Novus Biologicals
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MARCH5-Antibody-N-term-Blocking-peptide - BP5677a from Abgent, a WuXi AppTec company
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RNF153 Blocking Peptide - 33R-9713 from Fitzgerald
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RNF153 Blocking Peptide - 33R-1794 from Fitzgerald
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MARCH5 - H00054708-P01-10 from Acris Antibodies
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MARCH5 - H00054708-P01-25 from Acris Antibodies
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MARCH5 - H00054708-Q01-10 from Acris Antibodies
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MARCH5 - H00054708-Q01-25 from Acris Antibodies
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MARCH5 fusion protein - ag8286 from Proteintech Group
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MARCH5 fusion protein - ag2806 from Proteintech Group
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MARCH5 Blocking Peptide - CBP4325 from Cohesion Biosciences
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MARCH5 Blocking Peptide - abx161536 from Abbexa
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MARCH5 Protein - NBP2-33050PEP from Novus Biologicals
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MARCH6 Recombinant Protein Antigen - NBP2-38987PEP from Novus Biologicals
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MARCH5 Peptide, Human - M34GP09227H from Creative Peptides
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E3 ubiquitin-protein ligase MARCH5 (MARCH5), Recombinant Protein - MBS7006881 from MyBioSource
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MARCH5 Recombinant Protein Antigen - NBP2-56779PEP from Novus Biologicals
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