| Gene Symbol |
PCK1
|
| Entrez Gene |
5105
|
| Alt Symbol |
PEPCK-C, PEPCK1, PEPCKC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoenolpyruvate carboxykinase 1 (soluble)
|
| Other Description |
PEP carboxykinase|phosphoenolpyruvate carboxykinase, cytosolic|phosphoenolpyruvate carboxykinase, cytosolic [GTP]|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase
|
| Swissprots |
Q8TCA3 A8K437 Q9UJD2 P35558 B4DT64
|
| Accessions |
AAA02558 AAA91026 AAV50001 EAW75514 EAW75515 P35558 AI635748 AK290802 BAF83491 AK300072 BAG61876 AK303806 BAG64760 AW007566 BC023978 AAH23978 BJ993061 BM758256 BM768055 BX648510 DB187814 DQ893518 ABM84444 DQ896497 ABM87496 L05144 AAA60084 XM_011528839 XP_011527141 NM_002591 NP_002582
|
| Function |
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Major sites of expression are liver, kidney and adipocytes.
|
| Top Pathways |
Glucagon signaling pathway, Glycolysis / Gluconeogenesis, AMPK signaling pathway, PI3K-Akt signaling pathway, Proximal tubule bicarbonate reclamation
|
![Western Blot: PCK1 Overexpression Lysate (Adult Normal) [NBL1-14179] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PCK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13925_PCK1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14179-img0002.jpg)