| Gene Symbol | PCK1 |
|---|---|
| Entrez Gene | 5105 |
| Alt Symbol | PEPCK-C, PEPCK1, PEPCKC |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphoenolpyruvate carboxykinase 1 (soluble) |
| Other Description | PEP carboxykinase|phosphoenolpyruvate carboxykinase, cytosolic|phosphoenolpyruvate carboxykinase, cytosolic [GTP]|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase |
| Swissprots | Q8TCA3 A8K437 Q9UJD2 P35558 B4DT64 |
| Accessions | AAA02558 AAA91026 AAV50001 EAW75514 EAW75515 P35558 AI635748 AK290802 BAF83491 AK300072 BAG61876 AK303806 BAG64760 AW007566 BC023978 AAH23978 BJ993061 BM758256 BM768055 BX648510 DB187814 DQ893518 ABM84444 DQ896497 ABM87496 L05144 AAA60084 XM_011528839 XP_011527141 NM_002591 NP_002582 |
| Function | Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Major sites of expression are liver, kidney and adipocytes. |
| Top Pathways | Glucagon signaling pathway, Glycolysis / Gluconeogenesis, AMPK signaling pathway, PI3K-Akt signaling pathway, Proximal tubule bicarbonate reclamation |