S100A9

Gene Symbol	S100A9
Entrez Gene	6280
Alt Symbol	60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14
Species	Human
Gene Type	protein-coding
Description	S100 calcium binding protein A9
Other Description	MRP-14|S100 calcium-binding protein A9 (calgranulin B)|calgranulin B|calgranulin-B|calprotectin L1H subunit|leukocyte L1 complex heavy chain|migration inhibitory factor-related protein 14|protein S100-A9
Swissprots	Q9UCJ1 Q6FGA1 P06702 D3DV36 Q9NYM0
Accessions	AAA36326 AAF62536 AAF62537 CAA01002 CAA01003 CAA01004 EAW53333 EAW53334 P06702 AF086362 AK311882 BAG34823 BC047681 AAH47681 CR542207 CAG47003 CR542224 CAG47020 M26311 AAA68480 X06233 CAA29579 NM_002965 NP_002956
Function	S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellula
Subcellular Location	Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.
Tissue Specificity	Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin ca

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human S100A9 full length protein - ab95909 from Abcam Category Protein Source E. coli Species Human

Human S100A9 peptide - ab74434 from Abcam Category Peptide

Mouse S100A9 full length protein - ab109951 from Abcam Category Protein Source E. coli Species Mouse

S100A9 / MRP14 Antibody Blocking Peptide - LS-E20541 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

S100A9 / MRP14 Antibody Blocking Peptide - LS-E26976 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human S100A9 Protein - NBP1-44500 from Novus Biologicals Category Protein Prices $299.00, $649.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Recombinant Human S100A9 Protein - H00006280-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Mouse S100A9 Protein - NBP1-72366 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli

S100A9 Protein (OPPA00090) - OPPA00090 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Escherichia Coli.

S100A9 Protein (OPPA02363) - OPPA02363 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human S100A9 His tag protein - orb83590 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Insect Species Human

Human S100A9 (His tag) protein - orb169242 from Biorbyt Category Protein Prices $170.00, $315.00 Sizes 2 μg, 10 μg Source E. coli

Human S100A9 protein - orb244516 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human S100 Calcium Binding Protein A9 protein - orb81339 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 25 μg Source E.coli Species Human

Human S100A9 protein - orb83561 from Biorbyt Category Protein Prices $434.00, $646.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human S100A9 protein - orb245978 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Mouse Calprotectin protein - orb169243 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Mouse

S100A9 Blocking Peptide - 33R-6535 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

S100A9 protein - 30-1383 from Fitzgerald Category Protein Prices $335.00 Sizes 500 µg Source E.coli

Human S100A9 Protein - abx068975 from Abbexa Category Protein Source E.coli Species Human

S100A9 Peptide - AC21-1803-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

S100A9 / Calgranulin-B / MRP14 (1-114, His-tag) - AR09453PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

S100A9 / Calgranulin-B / MRP14 (1-114, His-tag) - AR09453PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

S100A9 / Calgranulin-B / MRP14 - H00006280-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

S100A9 / Calgranulin-B / MRP14 - H00006280-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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