CASP1

Gene Symbol	CASP1
Entrez Gene	834
Alt Symbol	ICE, IL1BC, P45
Species	Human
Gene Type	protein-coding
Description	caspase 1, apoptosis-related cysteine peptidase
Other Description	CASP1 nirs variant 1|IL-1 beta-converting enzyme|IL1B-convertase|caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)|caspase-1|interleukin 1, beta, convertase|interleukin 1-B converting enzyme
Swissprots	P29466 Q9UCN3 Q6PI75 Q6GSS3 Q53EY6 B5MDZ1 Q6DMQ1
Accessions	AAD15243 EAW67057 EAW67058 EAW67059 EAW67060 EAW67061 P29466 AA505065 AA737419 AA761907 AB102878 BAD89407 AK223503 BAD97223 AK290114 BAF82803 AK290122 BAF82811 AK296646 BAG59246 AK301037 BAG62650 AK310059 AK313516 BAG36296 AY660536 AAT72297 BC041689 AAH41689 BC062327 AAH62327 HQ447656 ADQ32141 M87507 AAA66942 U13697 AAC50107 U13698 AAC50108 U13699 AAC50109 U13700 AAC50110 X65019 CAA46153 XM_006718924 XP_006718987 XM_011543017 XP_011541319 XM_011543018 XP_011541320 NM_001223 NP_001214 NM_001257118 NP_001244047 NM_001257119 NP_001244048 NM_033292 NP_150634 NM_033293 NP_150635 NM_033294 NP_150636 NM_033295 NP_150637
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269|PubMed:15498465, ECO:0000269|PubMed:7876192}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269|PubMed:15498465}.
Top Pathways	Amyotrophic lateral sclerosis (ALS), NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Pertussis, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CASP1 gene - orb91642 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-CASP1-cDNA-Clone - DC08245 from Abgent, a WuXi AppTec company Prices $419.85 Sizes 10 µg Species Human Accession BC062327

CASP1 - MBS1266513 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC062327

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone in cloning vector - HG11148-M from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-HA tag - HG11148-CY from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11148-M-F from Sino Biological Species Human

Human CASP1 transcript variant alpha Gene cDNA Clone (full-length ORF Clone), expression ready, C-OFPSpark tag - HG11148-ACR from Sino Biological Species Human Accession NM_033292.2

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11148-ANR from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid - HG11148-UT from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11148-ACG from Sino Biological Species Human

Human CASP1 transcript variant alpha Gene cDNA Clone (full-length ORF Clone), expression ready, N-HA-tagged - HG11148-NY from Sino Biological Species Human Accession NM_033292.2

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-His tag - HG11148-NH from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11148-NF from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11148-NM from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11148-ANG from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11148-CF from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-His tag - HG11148-CH from Sino Biological Species Human

Human Caspase-1/CASP1 transcript variant alpha Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11148-CM from Sino Biological Species Human

CASP1 - CL01311H01 from Elabscience Species Human Accession NM_033292.3

CASP1 - CL01311H02 from Elabscience Species Human Accession NM_001223.4

Human CASP1 ORF Clone(NM_033295.3) - CDCR313734 from Creative biogene Species Human

Human CASP1 ORF Clone (BC062327) - CDCS409725 from Creative biogene Species Human Accession P29466

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