Gene Symbol | lpxM |
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Entrez Gene | 945143 |
Alt Symbol | ECK1856, JW1844, mlt, msbB, waaN |
Species | Escherichia coli |
Gene Type | protein-coding |
Description | myristoyl-acyl carrier protein (ACP)-dependent acyltransferase |
Other Description | - |
Swissprots | P24205 |
Accessions | AAC74925 NP_416369 |
Function | Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold- adapted Kdo(2)-lipid A. In vitro, can acylate Kdo(2)-lipid IV(A), but acylation of (KDO)2-(lauroyl)-lipid IV(A) is about 100 times faster. In vitro, can use lauroyl-ACP but displays a slight kinetic preference for myristoyl-ACP. {ECO:0000269|PubMed:9099672, ECO:0000305|PubMed:10092655}. |
Subcellular Location | Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_01944, ECO:0000269|PubMed:9099672}; Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01944}. |
Top Pathways | Lipopolysaccharide biosynthesis |
Recombinant Escherichia coli Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase ,partial - CSB-YP332971ENV1 from Cusabio
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Lipid A biosynthesis (KDO)2- (lauroyl)-lipid IVA acyltransferase, Recombinant Protein - MBS1007995 from MyBioSource
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Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (msbB), Recombinant Protein - MBS7020961 from MyBioSource
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