PIM1

Gene Symbol	PIM1
Entrez Gene	5292
Alt Symbol	PIM
Species	Human
Gene Type	protein-coding
Description	Pim-1 proto-oncogene, serine/threonine kinase
Other Description	Oncogene PIM1|pim-1 kinase 44 kDa isoform|pim-1 oncogene (proviral integration site 1)|proto-oncogene serine/threonine-protein kinase pim-1|serine/threonine-protein kinase pim-1
Swissprots	Q38RT9 Q96RG3 P11309 Q5T7H7
Accessions	AAA60090 AAK70871 EAX03934 EAX03935 P11309 AK301158 BAG62748 AK301314 BAG62865 AK309347 BC020224 AAH20224 DA434260 DA481890 DA489942 DQ022562 AAY87461 M16750 AAA60089 M24779 AAA81553 M54915 AAA36447 NM_001243186 NP_001230115 NM_002648 NP_002639
Function	Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl- X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis.
Subcellular Location	Isoform 2: Cytoplasm. Nucleus.
Tissue Specificity	Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. {ECO:0000269|PubMed:16186805}.
Top Pathways	Jak-STAT signaling pathway, Acute myeloid leukemia, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Oncogene PIM1 Gene - orb92225 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-PIM1-cDNA-Clone - DC04879 from Abgent, a WuXi AppTec company Prices $422.55 Sizes 10 µg Species Human Accession NM_002648

PIM1 - MBS1269470 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC020224

Human PIM1 Gene ORF cDNA clone in cloning vector - HG11537-M from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid - HG11537-UT from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11537-ACG from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11537-NY from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11537-CY from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11537-NH from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11537-CH from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11537-NF from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11537-NM from Sino Biological Species Human

Human PIM1 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG11537-M-F from Sino Biological Species Human Accession NM_002648.3

Human PIM1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11537-CF from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid - HG11537-M-N from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11537-CM from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11537-ACR from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11537-ANR from Sino Biological Species Human

Human PIM1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11537-ANG from Sino Biological Species Human

Human PIM1 ORF clone(NM_002648.3) - CDCL185720 from Creative biogene Species Human

human PIM1 ORF clone (NM_001243186.1) - CDCH063962 from Creative biogene Species Human

Human PIM1 ORF Clone (BC020224) - CDCS409843 from Creative biogene Species Human Accession P11309

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