| Gene Symbol |
IGF2BP1
|
| Entrez Gene |
395953
|
| Alt Symbol |
ZBP1
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor 2 mRNA binding protein 1
|
| Other Description |
IGF-II mRNA-binding protein 1|IGF2 mRNA-binding protein 1|IMP-1|VICKZ family member 1|ZBP-1|insulin-like growth factor 2 mRNA-binding protein 1|zip code-binding protein 1|zip-code binding polypeptide|zipcode-binding protein 1
|
| Swissprots |
O42254
|
| Accessions |
O42254 AF026527 AAB82295 NM_205071 NP_990402
|
| Function |
RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta-actin/ACTB mRNA translation in polarized cells, a crucial process for cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mRNA in the nucleus. This binding involves by a conserved 54- nucleotide element in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The ribonucleoparticle (RNP) thus formed is exported to the cytoplasm, binds to a motor protein and is transported along the cytoskeleton to the cell periphery. During transport, IGF2BP1
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, filopodium. Cell projection, lamellipodium. Note=In the nucleus, located in discrete foci, coinciding with the sites of ACTB transcription. Export from the nucleus is mediated by XPO1. In the cytoplasm, colocalizes with ACTB mRNA at the leading edge, in growth cone filopodia and along neurites. In these locations, also colocalizes with microtubules. Colocalization with ACTB mRNA is partially lost at the cell periphery, suggesting release of the transcript. In neuronal processes, exhibits fast retrograde and anterograde movements, when associated with ACTB mRNA; this motility is lost when the association is inhibited. In migrating fibroblasts, localizes not only to leading edges, but also to retracting tails. In response to cellular stress, such as oxidative stress or heat shock, recruited to stress granules.
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| Tissue Specificity |
Expressed in neurons and embryonic fibroblasts (at protein level). {ECO:0000269|PubMed:11502257, ECO:0000269|PubMed:9121465}.
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