| Gene Symbol |
CCNDBP1
|
| Entrez Gene |
23582
|
| Alt Symbol |
DIP1, GCIP, HHM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cyclin D-type binding-protein 1
|
| Other Description |
D-type cyclin-interacting protein 1|cyclin-D1-binding protein 1|grap2 and cyclin-D-interacting protein|human homolog of Maid
|
| Swissprots |
Q9NYH3 Q6ZQN9 A8K3Q0 O95273 A8K3U2 Q9UHX9 Q7Z519 Q8NBY2 Q9NS19 Q8NBS7
|
| Accessions |
CAJ21094 EAW92588 EAW92589 EAW92590 O95273 AF082569 AAD11777 AF087852 AAP97163 AF113535 AAF14872 AF132034 AAF77613 AF246144 AAF67182 AI953224 AK075146 BAC11433 AK075296 BAC11530 AK124193 BAG54020 AK128849 BAC87645 AK225143 AK225645 AK290665 BAF83354 AK290707 BAF83396 AK295017 BAG58076 AK308817 AL552334 BC009689 AAH09689 BI911845 BQ439439 CB104739 CR450331 CAG29327 DA210890 DA506028 DA734945 DB492361 DQ894124 ABM85050 XM_006720448 XP_006720511 XR_429445 NM_012142 NP_036274 NR_027513 NR_027514 NR_045998 NR_045999 NM_037370
|
| Function |
May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. {ECO:0000269|PubMed:10801854}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Ubiquitously expressed. Expression is down- regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. {ECO:0000269|PubMed:10801854, ECO:0000269|PubMed:10854051, ECO:0000269|PubMed:10915743, ECO:0000269|PubMed:15887118, ECO:0000269|PubMed:17131381}.
|