| Gene Symbol |
AR
|
| Entrez Gene |
403588
|
| Alt Symbol |
-
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
androgen receptor
|
| Other Description |
androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease)|dihydrotestosterone receptor|nuclear receptor subfamily 3 group C member 4
|
| Swissprots |
Q6WSP7 Q9TT90
|
| Accessions |
Q9TT90 AF197950 AAF18084 AY271347 AAQ84563 NM_001003053 NP_001003053
|
| Function |
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1 (By similarity). {ECO:0000250}.
|
| Top Pathways |
Prostate cancer, Oocyte meiosis
|