| Gene Symbol |
CHPT1
|
| Entrez Gene |
56994
|
| Alt Symbol |
CPT, CPT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
choline phosphotransferase 1
|
| Other Description |
AAPT1-like protein|cholinephosphotransferase 1|cholinephosphotransferase 1 alpha|diacylglycerol cholinephosphotransferase 1|hCPT1|phosphatidylcholine synthesizing enzyme
|
| Swissprots |
Q7Z7H0 Q8WUD6 Q7Z7H2 Q8IWQ4 Q9Y6M6 Q9NRQ6 Q8IWQ5 Q7Z7H1 Q8WYI4 B3KQM2 Q9NRQ7
|
| Accessions |
CAF86967 EAW97673 EAW97674 EAW97675 EAW97676 EAW97677 Q8WUD6 AF047431 AAD44019 AF111803 AAL39005 AF195623 AAF87947 AF195624 AAF87948 AK075211 BAG52084 AK093067 BAG52647 AK226127 AY166717 AAN86122 AY166718 AAN86123 AY280609 AAP34412 AY280610 AAP34413 AY294627 AAP37157 BC020819 AAH20819 BC050429 AAH50429 CD300296 XM_011538574 XP_011536876 XM_011538575 XP_011536877 XR_245946 NM_020244 NP_064629
|
| Function |
Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000269|PubMed:12221122}; Multi-pass membrane protein {ECO:0000269|PubMed:12221122}.
|
| Tissue Specificity |
Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines. {ECO:0000269|PubMed:10893425, ECO:0000269|PubMed:12359261}.
|
| Top Pathways |
Choline metabolism in cancer, Ether lipid metabolism, Glycerophospholipid metabolism
|
