| Gene Symbol |
Scn1b
|
| Entrez Gene |
29686
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, voltage-gated, type I, beta subunit
|
| Other Description |
sodium channel subunit beta-1|sodium channel voltage-gated type 1 beta polypeptide|sodium channel voltage-gated type I beta polypeptide|sodium channel, voltage-gated, type 1, beta polypeptide|sodium channel, voltage-gated, type I, beta polypeptide
|
| Swissprots |
Q505J0 Q00954
|
| Accessions |
AAB02428 EDM07660 EDM07661 EDM07662 Q00954 AF182949 AAF25186 BC094523 AAH94523 FQ215379 FQ216374 L34417 M91808 AAA88513 NM_001271045 NP_001257974 NM_001271046 NP_001257975 NM_017288 NP_058984
|
| Function |
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed in brain, heart, skeletal muscle and spinal cord.
|
| Top Pathways |
Adrenergic signaling in cardiomyocytes
|