| Gene Symbol | MMP2 |
|---|---|
| Entrez Gene | 4313 |
| Alt Symbol | CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 2 |
| Other Description | 72 kDa type IV collagenase|collagenase type IV-A|matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|matrix metalloproteinase-2|matrix metalloproteinase-II|neutrophil gelatinase |
| Swissprots | E9PE45 B4DWH3 B2R6U1 P08253 Q9UCJ8 |
| Accessions | AAA52027 AAA52028 AAU10089 CAR95108 CAS92766 EAW82824 EAW82825 EAW82826 EAW82827 EAW82828 P08253 AK301536 BAG63035 AK310314 AK312711 BAG35588 AL046162 AL542407 AL832088 AU133104 AU279927 BC002576 AAH02576 BP341649 BQ004983 BX357054 CA446916 DA579926 DA739456 DA993141 DB059054 DB154582 DQ385623 ABD38929 DQ891952 ABM82878 DQ895138 ABM86064 J03210 AAA35701 X58968 NM_001127891 NP_001121363 NM_001302508 NP_001289437 NM_001302509 NP_001289438 NM_001302510 NP_001289439 NM_004530 NP_004521 |
| Function | Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro- inflammatory NF-kappaB, NFAT and IRF transcriptional pathways. |
| Subcellular Location | Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes. |
| Tissue Specificity | Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. {ECO:0000269|PubMed:11751392}. |
| Top Pathways | Leukocyte transendothelial migration, Bladder cancer, GnRH signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer |