IL6

Gene Symbol IL6
Entrez Gene 100034196
Alt Symbol IL-6
Species Horse
Gene Type protein-coding
Description interleukin 6 (interferon, beta 2)
Other Description interleukin-6
Swissprots O46568 Q95181 O19007
Accessions Q95181 AF005227 AAB62246 AF041975 AAC04574 EU438770 ABZ91979 U64794 AAB87703 XM_005609172 XP_005609229 NM_001082496 NP_001075965
Function Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}.
Subcellular Location Secreted.
Top Pathways TNF signaling pathway, Legionellosis, Herpes simplex infection, PI3K-Akt signaling pathway, African trypanosomiasis

IL-6 Antibody [Unconjugated] - AF1886 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Recombinant Equine IL‑6 (Catalog # 1886-EL) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Equine IL‑6 (4 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Equine IL‑6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1886). The ND50 is typically 0.5‑1.5 µg/mL.

IL-6 Antibody [Biotin] - BAF1886 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
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