| Gene Symbol |
IL6
|
| Entrez Gene |
100034196
|
| Alt Symbol |
IL-6
|
| Species |
Horse
|
| Gene Type |
protein-coding
|
| Description |
interleukin 6 (interferon, beta 2)
|
| Other Description |
interleukin-6
|
| Swissprots |
O46568 Q95181 O19007
|
| Accessions |
Q95181 AF005227 AAB62246 AF041975 AAC04574 EU438770 ABZ91979 U64794 AAB87703 XM_005609172 XP_005609229 NM_001082496 NP_001075965
|
| Function |
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
TNF signaling pathway, Legionellosis, Herpes simplex infection, PI3K-Akt signaling pathway, African trypanosomiasis
|
