Gene Symbol | CXCL3 |
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Entrez Gene | 2921 |
Alt Symbol | CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-X-C motif) ligand 3 |
Other Description | C-X-C motif chemokine 3|GRO-gamma|GRO-gamma(1-73)|GRO3 oncogene|MGSA gamma|MIP2-beta|growth-regulated protein gamma|macrophage inflammatory protein 2-beta|melanoma growth stimulatory activity gamma |
Swissprots | P19876 Q4W5H9 |
Accessions | AAA03454 AAP13105 AAY41006 CBX54349 EAX05697 EAX05698 P19876 AK307064 AK311367 AW079760 BC016308 AAH16308 BC065743 AAH65743 BM828712 EU176452 ABW03903 EU831482 ACE87169 EU831569 ACE86488 M36821 AAA63184 X53800 CAA37809 NM_002090 NP_002081 |
Function | Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. {ECO:0000250, ECO:0000269|PubMed:10095777}. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Salmonella infection, Legionellosis, TNF signaling pathway |
GROγ CRISPR/Cas9 KO Plasmid (h) - sc-416451 from Santa Cruz Biotechnology
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GROγ HDR Plasmid (h) - sc-416451-HDR from Santa Cruz Biotechnology
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GROγ Double Nickase Plasmid (h) - sc-416451-NIC from Santa Cruz Biotechnology
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GROγ Double Nickase Plasmid (h2) - sc-416451-NIC-2 from Santa Cruz Biotechnology
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GROγ CRISPR Activation Plasmid (h) - sc-416451-ACT from Santa Cruz Biotechnology
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GROγ CRISPR Activation Plasmid (h2) - sc-416451-ACT-2 from Santa Cruz Biotechnology
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GROγ Lentiviral Activation Particles (h) - sc-416451-LAC from Santa Cruz Biotechnology
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GROγ Lentiviral Activation Particles (h2) - sc-416451-LAC-2 from Santa Cruz Biotechnology
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GROγ siRNA (h) - sc-43815 from Santa Cruz Biotechnology
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GROγ shRNA Plasmid (h) - sc-43815-SH from Santa Cruz Biotechnology
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GROγ shRNA (h) Lentiviral Particles - sc-43815-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU147761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6805 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6805 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05838 from Sigma-Aldrich
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CXCL3 siRNA (Human) - CRH1974 from Cohesion Biosciences
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CXCL3 - MBS829799 from MyBioSource
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shRNA set against Human CXCL3 (NM_002090.2) - SHH272213 from Creative biogene
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Human CXCL3 siRNA - orb262476 from Biorbyt
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CXCL3 shRNA Plasmid (Human) - CHH1974 from Cohesion Biosciences
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CXCL3 miRNA 3'UTR clone - MiUTR1H-02574 from Creative biogene
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