| Gene Symbol | CXCL3 |
|---|---|
| Entrez Gene | 2921 |
| Alt Symbol | CINC-2b, GRO3, GROg, MIP-2b, MIP2B, SCYB3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chemokine (C-X-C motif) ligand 3 |
| Other Description | C-X-C motif chemokine 3|GRO-gamma|GRO-gamma(1-73)|GRO3 oncogene|MGSA gamma|MIP2-beta|growth-regulated protein gamma|macrophage inflammatory protein 2-beta|melanoma growth stimulatory activity gamma |
| Swissprots | P19876 Q4W5H9 |
| Accessions | AAA03454 AAP13105 AAY41006 CBX54349 EAX05697 EAX05698 P19876 AK307064 AK311367 AW079760 BC016308 AAH16308 BC065743 AAH65743 BM828712 EU176452 ABW03903 EU831482 ACE87169 EU831569 ACE86488 M36821 AAA63184 X53800 CAA37809 NM_002090 NP_002081 |
| Function | Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. {ECO:0000250, ECO:0000269|PubMed:10095777}. |
| Subcellular Location | Secreted. |
| Top Pathways | Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Salmonella infection, Legionellosis, TNF signaling pathway |