| Gene Symbol |
Aimp2
|
| Entrez Gene |
100682533
|
| Alt Symbol |
JTV1
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
|
| Other Description |
Multisynthase complex auxiliary component p38|Protein JTV-1|aminoacyl tRNA synthase complex-interacting multifunctional protein 2|multisynthetase complex p38 auxiliary component
|
| Swissprots |
Q9WVM7
|
| Accessions |
EGV95752 ERE76342 Q9WVM7 AF072727 AAD38422 NM_001243983 NP_001230912
|
| Function |
Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000250}.
|