GLI2
| Gene Symbol | GLI2 |
|---|---|
| Entrez Gene | 2736 |
| Alt Symbol | CJS, HPE9, PHS2, THP1, THP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | GLI family zinc finger 2 |
| Other Description | GLI family zinc finger protein 2|GLI-Kruppel family member GLI2|glioma-associated oncogene family zinc finger 2|oncogene GLI2|tax helper protein 1|tax helper protein 2|tax-responsive element-2 holding protein|tax-responsive element-25-bp sequence binding protein|zinc finger protein GLI2 |
| Swissprots | O60255 O60252 Q4JHT4 O60254 Q15591 O60253 P10070 Q15590 |
| Accessions | AAA35898 P10070 AB007295 BAA25665 AB007296 BAA25666 AB007297 BAA25667 AB007298 BAA25668 AB209354 BAD92591 AJ707583 AK300071 BAG61875 AY493737 AAS72889 AY493738 AAS72890 AY493739 AAS72891 BC111410 AAI11411 BC172434 AAI72434 D14827 BAA03568 D14828 BAA03569 DQ004396 AAY58315 DQ004397 AAY58316 DQ004398 AAY58317 DQ086814 AAY87165 EF547128 XM_006712422 XP_006712485 XM_011510969 XP_011509271 XM_011510970 XP_011509272 XM_011510971 XP_011509273 XM_011510972 XP_011509274 XM_011510973 XP_011509275 XM_011510974 XP_011509276 NM_005270 NP_005261 NM_030379 NM_030380 NM_030381 |
| Function | Isoform 5: Acts as a transcriptional repressor. {ECO:0000269|PubMed:15994174}. |
| Subcellular Location | Isoform 2: Nucleus {ECO:0000269|PubMed:9557682}. |
| Tissue Specificity | Isoform 1 and isoform 4 are expressed in HTLV- 1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines. {ECO:0000269|PubMed:9557682}. |
| Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, Hippo signaling pathway |
GLI-2 CRISPR/Cas9 KO Plasmid (h) - sc-400839 from Santa Cruz Biotechnology
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GLI-2 HDR Plasmid (h) - sc-400839-HDR from Santa Cruz Biotechnology
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GLI-2 Double Nickase Plasmid (h) - sc-400839-NIC from Santa Cruz Biotechnology
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GLI-2 Double Nickase Plasmid (h2) - sc-400839-NIC-2 from Santa Cruz Biotechnology
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GLI-2 CRISPR Activation Plasmid (h) - sc-400839-ACT from Santa Cruz Biotechnology
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GLI-2 CRISPR Activation Plasmid (h2) - sc-400839-ACT-2 from Santa Cruz Biotechnology
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GLI-2 Lentiviral Activation Particles (h) - sc-400839-LAC from Santa Cruz Biotechnology
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GLI-2 Lentiviral Activation Particles (h2) - sc-400839-LAC-2 from Santa Cruz Biotechnology
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GLI-2 siRNA (h) - sc-37913 from Santa Cruz Biotechnology
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GLI-2 shRNA Plasmid (h) - sc-37913-SH from Santa Cruz Biotechnology
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GLI-2 shRNA (h) Lentiviral Particles - sc-37913-V from Santa Cruz Biotechnology
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GLI-2 RNAi - H00002736-R02 from Novus Biologicals
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GLI-2 RNAi - H00002736-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN9340 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9340 from Sigma-Aldrich
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GLI2 siRNA (Human) - CRH1820 from Cohesion Biosciences
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GLI-2 RNAi - H00002736-R04 from Novus Biologicals
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GLI-2 RNAi - H00002736-R03 from Novus Biologicals
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GLI2 - MBS8212620 from MyBioSource
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shRNA set against Human GLI2 (NM_005270.4) - SHH301750 from Creative biogene
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Human GLI2 siRNA - orb262322 from Biorbyt
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GLI2 shRNA Plasmid (Human) - CHH1820 from Cohesion Biosciences
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GLI2 miRNA 3'UTR clone - MiUTR3H-01637 from Creative biogene
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