Gene Symbol | TFB2M |
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Entrez Gene | 64216 |
Alt Symbol | Hkp1, mtTFB2 |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor B2, mitochondrial |
Other Description | HCV NS5A-transactivated protein 5|S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2|dimethyladenosine transferase 2, mitochondrial|h-mtTFB|h-mtTFB2|hTFB2M|hepatitis C virus NS5A-transactivated protein 5|mitochondrial 12S rRNA dimethylase 2|mitochondrial transcription factor B2 |
Swissprots | Q9H626 Q9H5Q4 |
Accessions | EAW77149 EAW77150 EAW77151 EAW77152 EAW77153 Q9H5Q4 AF529366 AAQ09600 AK026314 BAB15441 AK026835 BAB15566 AK300238 BAG62006 BC003383 AAH03383 CK725134 DA038232 EU446518 ABZ92047 XM_011544248 XP_011542550 NM_022366 NP_071761 |
Function | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300}. |
Subcellular Location | Mitochondrion. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12068295}. |
TFB2M (N-13) - sc-160859 from Santa Cruz Biotechnology
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TFB2M (D-13) - sc-160856 from Santa Cruz Biotechnology
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TFB2M (X-23) - sc-134078 from Santa Cruz Biotechnology
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Anti-TFB2M antibody - ab13676 from Abcam
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Anti-TFB2M antibody - ab66014 from Abcam
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Anti-TFB2M antibody - ab88187 from Abcam
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Anti-TFB2M antibody - ab116608 from Abcam
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Anti-TFB2M antibody - ab107685 from Abcam
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Anti-TFB2M antibody - N-terminal - ab187115 from Abcam
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Anti-TFB2M Antibody (aa101-150) - LS-C80090 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396) - LS-C161818 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa81-94) - LS-C139799 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa383-396) IHC-plus⢠- LS-B11146 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa325-338) IHC-plus⢠- LS-B10472 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396, AP) - LS-C217934 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396, Biotin) - LS-C217936 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396, APC) - LS-C217935 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396, FITC) - LS-C217937 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396, Azide-free, HRP) - LS-C217938 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa368-396, PE) - LS-C217939 from LifeSpan Bioscience
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Anti-TFB2M Antibody (C-Terminus) - LS-C80268 from LifeSpan Bioscience
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Anti-TFB2M Antibody (aa375-404) - LS-C325678 from LifeSpan Bioscience
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Anti-TFB2M Antibody (N-Terminus) - LS-C116171 from LifeSpan Bioscience
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TFB2M Antibody - NBP1-82114 from Novus Biologicals
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TFB2M Antibody - H00064216-B01P from Novus Biologicals
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