ABCG2

Gene Symbol ABCG2
Entrez Gene 9429
Alt Symbol ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
Other Description ABC transporter|ATP-binding cassette sub-family G member 2|ATP-binding cassette transporter G2|breast cancer resistance protein|mitoxantrone resistance-associated protein|multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2|placenta specific MDR protein|placenta-specific ATP-binding cassette transporter|urate exporter
Swissprots Q9BY73 Q9NUS0 Q8IX16 O95374 A8K1T5 Q569L4 Q53ZQ1 Q4W5I3 A0A1W3 Q96LD6 Q96TA8 Q9UNQ0 Q5YLG4 Q86V64
Accessions AAY40902 ABI97388 CAF32512 EAX06012 EAX06013 Q9UNQ0 AB051855 BAB46933 AB056867 BAB39212 AF093771 AF093772 AF098951 AAC97367 AF103796 AAD09188 AF151530 AF463519 AAO14617 AK002040 BAA92050 AK290000 BAF82689 AY017168 AAG52982 AY288307 AAP31310 AY289766 AAP44087 AY333755 AAQ92941 AY333756 AAQ92942 BC011032 BC021281 AAH21281 BC092408 AAH92408 BI598784 DQ459561 DQ459562 DQ459563 DQ459564 DQ459565 DQ459566 DQ459567 DQ459568 DQ459570 DQ459571 DQ459572 DQ459573 DQ459574 DQ459575 DQ459576 DQ459577 DQ459578 DQ459579 DQ459580 DQ459581 DQ459582 DQ459583 DQ459584 DQ459585 DQ459586 DQ459587 DQ459588 DQ459589 DQ459590 DQ459591 DQ459592 DQ459593 DQ459594 DQ459595 DQ459596 DQ459597 DQ459598 DQ459599 DQ459600 DQ459601 DQ459602 DQ459603 DQ459604 DQ459605 DQ459606 DQ459607 DQ459608 DQ459609 DQ459610 DQ459611 DQ459612 DQ459613 DQ459614 DQ892308 ABM83234 DQ895507 ABM86433 HQ386990 ADO95109 HQ386991 ADO95110 HQ386992 ADO95111 HQ386993 ADO95112 HQ386994 ADO95113 HQ386995 ADO95114 HQ386996 ADO95115 HQ386997 ADO95116 HQ386998 ADO95117 HQ386999 ADO95118 HQ387000 ADO95119 HQ387001 ADO95120 HQ387002 ADO95121 HQ387003 ADO95122 HQ387004 ADO95123 HQ387005 ADO95124 HQ387006 ADO95125 HQ387007 ADO95126 U66681 XM_005263354 XP_005263411 XM_005263355 XP_005263412 XM_005263356 XP_005263413 XM_011532420 XP_011530722 NM_001257386 NP_001244315 NM_004827 NP_004818
Function High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. {ECO:0000269|PubMed:12958161, ECO:0000269|PubMed:20705604, ECO:0000269|PubMed:22132962, ECO:0000269|PubMed:23189181}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
Tissue Specificity Highly expressed in placenta. Low expression in small intestine, liver and colon. {ECO:0000269|PubMed:9850061, ECO:0000269|PubMed:9861027}.
Top Pathways ABC transporters, Bile secretion

ABCG2 Antibody - 4477 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS-7 cells, mock transfected (-) or transfected with a construct overexpressing human ABCG2 (+), using ABCG2 Antibody.

ABCG2 (B-1) - sc-377176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ABCG2 (B-1): sc-377176. Western blot analysis of ABCG2 expression in non-transfected 293T: sc-117752 (A), human ABCG2 transfected 293T: sc-172393 (B) and HL-60/MX1 (C) whole cell lysates.

ABCG2 (H-70) - sc-25821 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ABCG2 (H-70): sc-25821. Western blot analysis of ABCG2 expression in non-transfected: sc-117752 (A) and human ABCG2 transfected: sc-172393 (B) 293T whole cell lysates.

ABCG2 (5D3) - sc-18841 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ABCG2 (5D3) FITC: sc-18841 FITC. FCM analysis of HL-60/MX1 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>2b</sub>: sc-2857.

ABCG2 (BXP-21) - sc-58222 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
ABCG2 (BXP-21): sc-58222. Western blot analysis of ABCG2 expression in HL-60/MX-1 (A) and JAR (B) whole cell lysates.

ABCG2 (6D171) - sc-69988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Mouse
Clonality Monoclonal
ABCG2 (6D171): sc-69988. Western blot analysis of ABCG2 expression in JAR whole cell lysate.

ABCG2 (BXP-53) - sc-58224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Rat
Clonality Monoclonal
ABCG2 (BXP-53): sc-58224. Western blot analysis of ABCG2 expression in HL-60/MX-1 (A), JAR (B) and MCF7 (C) whole cell lysates.

ABCG2 (6D170) - sc-69989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 500 µl supernatant
Host Rat
Clonality Monoclonal
ABCG2 (6D170): sc-69989. Western blot analysis of ABCG2 expression in JAR (A) and MCF7 (B) whole cell lysates.

ABCG2 (B-25) - sc-130933 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ABCG2 (B-25): sc-130933. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human placenta tissue showing cytoplasmic and membrane localization.

Anti-BCRP/ABCG2 antibody - ab63907 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BCRP/ABCG2 antibody (ab63907) at 1 µg/ml + Placenta (Human) Tissue Lysate - adult normal tissue (ab29745) at 10 µgSecondarySecondary anti-rabbit antibody at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-BCRP/ABCG2 antibody - ab186770 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-BCRP/ABCG2 antibody - ab64756 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-BCRP/ABCG2 antibody (ab64756) at 1/60 dilution + 293 cell line lysates at 35 µg

Anti-BCRP/ABCG2 antibody [1H2] - ab130244 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H2
All lanes : Anti-BCRP/ABCG2 antibody [1H2] (ab130244) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : COS7 cell lysateLane 3 : Jurkat cell lysateLane 4 : NIH/3T3 cell lysate

Anti-BCRP/ABCG2 antibody [5D3] (Biotin) - ab95692 from Abcam

Prices $188.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 5D3
Staining of 3T3 cells transfected with Human BCRP/ABCG2 using 0.5µg of biotin-conjugated mouse IgG2b isotype control (open histogram) or 0.5 µg of ab95692 (filled histogram), followed by streptavidin PE. Total viable cells were used for analysis.

Anti-BCRP/ABCG2 antibody [BXP-21] - ab3380 from Abcam

Prices $394.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone BXP-21
ab3380 staining BCRP/ABCG2 in MCF7 human breast cancer cells by Immunocytochemistry/ Immunofluorescence.Cells were fixed in paraformaldehyde and permeabilized using 0.1% Triton X-100. Samples were then blocked using 10% serum for 2 hours at 25°C, then incubated with ab3380 at a 1/50 dilution for 12 hours at 4°C. A rabbit anti-mouse polyclonal conjugated to Alexa Fluor 594 was used as the secondary at a 1/50 dilution.See Abreview

Anti-BCRP/ABCG2 antibody [BXP-34] - ab3379 from Abcam

Prices $372.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone BXP-34

Anti-BCRP/ABCG2 antibody [EPR2099(2)] - ab108312 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2099(2)
All lanes : Anti-BCRP/ABCG2 antibody [EPR2099(2)] (ab108312) at 1/1000 dilutionLane 1 : Human fetal liver lysateLane 2 : JAR lysateLane 3 : 293T lysateLane 4 : HepG2 lysateLane 5 : Human placenta lysateLysates/proteins at 10 µg per lane.

Anti-BCRP/ABCG2 antibody [MM0047-2J39] - ab72788 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0047-2J39
ab72788 at 1/1000 dilution, staining BCRP/ABCG2 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-BCRP/ABCG2 antibody - Carboxyterminal end - ab64757 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BCRP/ABCG2 antibody - Carboxyterminal end (ab64757) at 1/60 dilution + HepG2 cell line lysates at 35 µg

ABCG2/CD338 Antibody (3G8) - NBP2-22124 from Novus Biologicals

Prices $129.00, $329.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G8
Western Blot: ABCG2 Antibody (3G8) [NBP2-22124] - Analysis of ABCG2 expression in 1) human small intestine, 2) human placenta and 3) mouse placenta tissue extracts.

ABCG2/CD338 Antibody (BXP-21) - NB100-2177 from Novus Biologicals

Prices $299.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone BXP-21
Immunocytochemistry: ABCG2/CD338 Antibody (BXP-21) [NB100-2177] - Staining in MCF7 human breast cancer cells. Cells were fixed in paraformaldehyde and permeabilized using 0.1% Triton X-100. Samples were then blocked using 10% serum for 2 hours at 25 C.

ABCG2/CD338 Antibody (5D3) - MAB995 from Novus Biologicals

Prices $99.00, $269.00, $699.00
Sizes 25 µg, 100 µg, 500 µg
Host Mouse
Clonality Monoclonal
Clone 5D3
ABCG2 was detected in immersion fixed Human ABCG2 transfected CHO Chinese hamster ovary cell line using Mouse Anti-Human ABCG2 Monoclonal Antibody (Catalog # MAB995) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

ABCG2/CD338 Antibody - NBP1-59749 from Novus Biologicals

Host Rabbit
Clonality Polyclonal
Western Blot: ABCG2 Antibody [NBP1-59749] - Titration: 2.5 ug/ml Positive Control: HepG2 cell lysate.

ABCG2/CD338 Antibody (1H2) - NBP2-22201 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H2
Western Blot: ABCG2/CD338 Antibody (1H2) [NBP2-22201] - Analysis using ABCG2 mouse mAb against HepG2 (1), Cos7 (2), Jurkat (3) and NIH/3T3 (4) cell lysate.

ABCG2/CD338 Antibody (MM0047-2J39) - NB110-93511 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0047-2J39
Immunohistochemistry-Paraffin: ABCG2 Antibody (MM0047-2J39) [NB110-93511] - Normal Human Placenta Tissue
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