RAD51

Gene Symbol	RAD51
Entrez Gene	5888
Alt Symbol	BRCC5, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
Species	Human
Gene Type	protein-coding
Description	RAD51 recombinase
Other Description	BRCA1/BRCA2-containing complex, subunit 5|DNA repair protein RAD51 homolog 1|RAD51 homolog A|RecA, E. coli, homolog of|RecA-like protein|recombination protein A
Swissprots	Q9BV60 B0FXP0 B2R8T6 Q6FHX9 Q6ZNA8 Q06609
Accessions	AAD49705 AAF61901 AAF69145 AAN87149 EAW92431 EAW92432 EAW92433 EAW92434 EAW92435 Q06609 AK131299 BAD18467 AK291969 BAF84658 AK303089 BAG64200 AK313503 BAG36283 AU100170 AY425955 AAR07948 AY608888 AAT37157 BC001459 AAH01459 BT019705 AAV38511 CR536559 CAG38796 D13804 BAA02962 D14134 BAA03189 EU362635 ABY59731 XM_006720626 XP_006720689 XM_011521857 XP_011520159 XM_011521858 XP_011520160 XM_011521859 XP_011520161 XM_011521860 XP_011520162 XM_011521861 XP_011520163 XM_011521862 XP_011520164 NM_001164269 NP_001157741 NM_001164270 NP_001157742 NM_002875 NP_002866 NM_133487 NP_597994
Function	Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2- scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. {ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:12442171, ECO:0000269|PubMed:18417535, ECO:0000269|PubMed:20231364, ECO:0000269|PubMed:20348101, ECO:0000269|PubMed:20413593, ECO:0000269|PubMed:23509288, ECO:0000269|PubMed:23754376}.
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner.
Tissue Specificity	Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
Top Pathways	Homologous recombination, Pancreatic cancer, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Rad51 full length protein - ab63808 from Abcam Category Protein Prices $302.00 Sizes 20 µg Source E. coli Species Human

Active RecA full length protein - ab123228 from Abcam Category Protein Prices $192.00 Sizes 100 µg Source E. coli

Human Rad51 (phospho T309) peptide - ab33130 from Abcam Category Peptide

Human Rad51 full length protein - ab81943 from Abcam Category Protein Source E. coli Species Human

Human Rad51 peptide - ab92664 from Abcam Category Peptide

Rad51 peptide - ab176353 from Abcam Category Peptide

RAD51 / RECA Antibody Blocking Peptide - LS-E11817 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Rad51 Protein - H00005888-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAD51-Antibody-Center-Blocking-Peptide - BP2825c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RAD51-Antibody-C-term-Blocking-Peptide - BP2825b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rad51-179-190 - SP2250b from Abgent, a WuXi AppTec company Category Peptide Prices $300.00 Sizes 5 mg

Rad51-175-190-CDB55 - SP2142a from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

RAD51 - H00005888-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAD51 - H00005888-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RAD51 fusion protein - Ag6823 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RAD51 fusion protein - Ag7410 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human NFIC, GST-tagged - NFIC-325H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RAD51 - RAD51-1121H from Creative Biomart Category Protein Source E.coli .

Recombinant Human RAD51, His-tagged - RAD51-29580TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RAD51 - RAD51-29581TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RAD51, GST-tagged - RAD51-2155H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RAD51 - RAD51-134H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant RAD51 Homolog (RAD51) - RPP750Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Rad51 (T309) Peptide - BS3729P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Rad51 (L302) Peptide - BS3771P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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