| Gene Symbol |
SCNN1B
|
| Entrez Gene |
489972
|
| Alt Symbol |
SCNEB
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
sodium channel, non-voltage-gated 1, beta subunit
|
| Other Description |
Amiloride-sensitive sodium channel subunit beta|beta-ENaC|beta-NaCH|epithelial Na(+) channel subunit beta|epithelial amiloride-sensitive sodium channel beta subunit|nonvoltage-gated sodium channel 1 subunit beta|sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)
|
| Swissprots |
Q95165
|
| Accessions |
AAB09034 Q95165 XM_005621420 XP_005621477 XM_005621421 XP_005621478
|
| Function |
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}. Note=Apical membrane of epithelial cells. {ECO:0000250}.
|
| Top Pathways |
Taste transduction, Aldosterone-regulated sodium reabsorption
|