| Gene Symbol |
COMT
|
| Entrez Gene |
100146509
|
| Alt Symbol |
-
|
| Species |
Horse
|
| Gene Type |
protein-coding
|
| Description |
catechol-O-methyltransferase
|
| Other Description |
catechol O-methyltransferase|catechol O-methyltransferase, membrane-bound form|catechol O-methyltransferase, soluble form
|
| Swissprots |
Q5H879 Q5H878
|
| Accessions |
Q5H879 AB178284 BAD89294 NM_001081834 NP_001075303 NM_001114535 NP_001108007
|
| Function |
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform 2: Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Steroid hormone biosynthesis, Dopaminergic synapse, Tyrosine metabolism
|