| Gene Symbol |
TJP1
|
| Entrez Gene |
403752
|
| Alt Symbol |
ZO-1, ZO1
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
tight junction protein 1 (zona occludens 1)
|
| Other Description |
tight junction protein ZO-1|zona occludens protein 1|zonula occludens 1|zonula occludens protein 1
|
| Swissprots |
O97758
|
| Accessions |
AAG43398 O97758 U55935 AAD11529 NM_001003140 NP_001003140
|
| Function |
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction {ECO:0000250}. Cell junction, gap junction {ECO:0000250}. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact. Detected at the leading edge of migrating and wounded cells (By similarity). {ECO:0000250}.
|
| Top Pathways |
Adherens junction, Tight junction, Gap junction, Salmonella infection
|
