| Gene Symbol |
Gbf1
|
| Entrez Gene |
100689421
|
| Alt Symbol |
-
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
golgi brefeldin A resistant guanine nucleotide exchange factor 1
|
| Other Description |
BFA-resistant GEF 1|golgi-specific brefeldin A-resistance factor 1|golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
|
| Swissprots |
Q9R1D7
|
| Accessions |
Q9R1D7 AF127523 AAD45661 JI883546 JI883547 JI892394 JI892395 JI892398 JI896176 JI896177 JP058921 JP058922 JP061706 JP061707 JP063146 XM_007648659 XP_007646849 XM_007648660 XP_007646850 NM_001246686 NP_001233615
|
| Function |
Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to cellular membranes such as the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments implicating ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmatic reticulum (ER). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably a
|
| Subcellular Location |
Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q92538}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q92538}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q92538}. Cytoplasm {ECO:0000250|UniProtKB:Q92538}. Lipid droplet {ECO:0000250|UniProtKB:Q92538}. Membrane; Peripheral membrane protein {ECO:0000305}. Note=Cycles rapidly on and off early Golgi membranes. Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (By similarity). {ECO:0000250|UniProtKB:Q92538}.
|
| Top Pathways |
Endocytosis
|