| Gene Symbol |
NR3C1
|
| Entrez Gene |
2908
|
| Alt Symbol |
GCCR, GCR, GCRST, GR, GRL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
|
| Other Description |
glucocorticoid nuclear receptor variant 1|glucocorticoid receptor
|
| Swissprots |
Q6N0A4 Q53EP5 P04151 D3DQF4 A0ZXF9 P04150 B0LPG8
|
| Accessions |
AAA88049 AAB20466 AAB64353 AAB64354 AAC34207 AAQ97180 ABY87547 ADP91134 ADP91135 ADP91136 ADP91137 ADP91138 ADP91139 ADP91140 ADP91141 ADP91142 ADP91143 ADP91144 ADP91145 ADP91146 ADP91147 ADP91148 ADP91149 ADP91150 ADP91151 ADP91152 ADP91153 ADP91154 ADP91155 ADP91156 ADP91157 ADP91158 ADP91159 ADP91160 ADP91161 ADP91162 ADP91163 ADP91164 ADP91165 ADP91166 ADP91167 ADP91168 ADP91169 ADP91170 ADP91171 ADP91172 ADP91173 ADP91174 ADP91175 ADP91176 ADP91177 ADP91178 ADP91179 ADP91180 ADP91181 ADP91182 ADP91183 ADP91184 ADP91185 ADP91186 ADP91187 ADP91188 ADP91189 ADP91190 ADP91191 ADP91192 ADP91193 ADP91194 ADP91195 ADP91196 ADP91197 ADP91198 ADP91199 ADP91200 ADP91201 ADP91202 ADP91203 ADP91204 ADP91205 ADP91206 ADP91207 ADP91208 ADP91209 ADP91210 ADP91211 ADP91212 ADP91213 ADP91214 ADP91215 ADP91216 ADP91217 ADP91218 ADP91219 ADP91220 ADP91221 ADP91222 ADP91223 ADP91224 ADP91225 ADP91226 ADP91227 ADP91228 ADP91229 ADP91230 ADP91231 ADP91232 ADP91233 ADP91234 ADP91235 ADP91236 ADP91237 ADP91238 ADP91239 ADP91240 ADP91241 ADP91242 ADP91243 ADP91244 ADP91245 ADP91246 ADP91247 ADP91248 ADP91249 ADP91250 ADP91251 ADP91252 ADP91253 CAM91161 CAR95142 CAR95143 CAR95144 CAR95145 CAR95146 CAR95147 CAR95148 EAW61870 EAW61871 EAW61872 EAW61873 P04150 AA737284 AB307716 BAH02307 AJ877166 CAI46893 AJ877167 CAI46894 AJ877168 CAI46895 AJ877169 CAI46896 AJ877170 CAI46897 AJ877171 CAI46898 AJ877172 CAI46899 AJ888004 CAI59612 AK223594 BAD97314 AK302050 BAH13618 AK314789 AM183262 CAJ65924 BC015610 AAH15610 BF244382 BF966114 BX640610 CAE45716 BX648553 CA425706 EU446477 ABZ92006 HQ450643 AED99114 HQ450644 AED99115 HQ692822 ADZ17333 JN797823 AFA52009 JN797824 AFA52010 U01351 AAA16603 U25029 AAD14820 X03225 CAA26976 X03348 CAA27054 XM_005268419 XP_005268476 XM_005268420 XP_005268477 XM_005268422 XP_005268479 XM_005268423 XP_005268480 XM_011537636 XP_011535938 XM_011537637 XP_011535939 NM_000176 NP_000167 NM_001018074 NP_001018084 NM_001018075 NP_001018085 NM_001018076 NP_001018086 NM_001018077 NP_001018087 NM_001020825 NP_001018661 NM_001024094 NP_001019265 NM_001204258 NP_001191187 NM_001204259 NP_001191188 NM_001204260 NP_001191189 NM_001204261 NP_001191190 NM_001204262 NP_001191191 NM_001204263 NP_001191192 NM_001204264 NP_001191193 NM_001204265 NP_001191194
|
| Function |
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression. {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:21664385}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946}. Mitochondrion. Nucleus {ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:17635946}. Note=Cytoplasmic in the absence of ligand, nuclear after ligand- binding.
|
| Tissue Specificity |
Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. {ECO:0000269|PubMed:10902803}.
|
| Top Pathways |
Neuroactive ligand-receptor interaction
|