DOCK7

Gene Symbol DOCK7
Entrez Gene 85440
Alt Symbol EIEE23, ZIR2
Species Human
Gene Type protein-coding
Description dedicator of cytokinesis 7
Other Description dedicator of cytokinesis protein 7
Swissprots Q5T1C0 Q96NG6 Q9C092 Q96NI0 Q96N67 Q45RE8 Q6ZV32 Q2PPY7 Q8TB82 Q45RE9 Q5T1B9 Q00M63
Accessions EAX06582 Q96N67 AB051558 BAB21862 AK022097 AK055296 AK055401 BAB70917 AK055493 BAB70933 AK055905 BAB71042 AK091479 BAG52372 AK125049 BAC86032 AK292640 BAF85329 AK299737 BAG61632 BC016392 AAH16392 BC018075 BC018076 BC041813 BC112387 AAI12388 BC172250 AAI72250 BG190976 BG205481 BG207092 BU567903 BU943181 BX094950 BX485492 DQ118679 AAZ38451 DQ118680 AAZ38452 DQ309763 ABC33725 DQ341187 ABC68221 DR002667 XM_005271292 XP_005271349 XM_011542326 XP_011540628 XM_011542327 XP_011540629 XM_011542328 XP_011540630 XM_011542329 XP_011540631 XM_011542330 XP_011540632 NM_001271999 NP_001258928 NM_001272000 NP_001258929 NM_001272001 NP_001258930 NM_001272002 NP_001258931 NM_033407 NP_212132
Function Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity). {ECO:0000250|UniProtKB:Q8R1A4, ECO:0000269|PubMed:16982419}.
Subcellular Location Cell projection, axon {ECO:0000269|PubMed:16982419}. Note=Enriched in the developing axons of hippocampal neurons.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11214970}.

DOCK 7 (A-6) - sc-398958 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOCK 7 (A-6): sc-398958. Western blot analysis of DOCK 7 expression in HeLa (A), JAR (B) and Jurkat (C) whole cell lysates.

DOCK 7 (C-7) - sc-398888 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DOCK 7 (C-7): sc-398888. Western blot analysis of DOCK 7 expression in HeLa (A) and Jurkat (B) whole cell lysates.

DOCK 7 (H-110) - sc-292123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

DOCK 7 (N-16) - sc-104220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

DOCK 7 (P-15) - sc-104221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DOCK 7 (P-15): sc-104221. Western blot analysis of DOCK 7 expression in HEK293 (A) and C6 (B) whole cell lysates.

Anti-DOCK7 antibody - ab118790 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab118790 stained U-87 MG cells. The cells were 4% fomaldeyhde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab118790, 1µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-DOCK7 antibody - ab71858 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DOCK7 antibody (ab71858) at 1/500 dilutionLane 1 : DOCK7 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-DOCK7 antibody [3540C1a] - ab84866 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3540C1a
Anti-DOCK7 antibody [3540C1a] (ab84866) + Immunogen (Recombinant Human DOCK7 fragment)

Anti-DOCK7 Antibody (clone 3540C1a) - LS-C342863 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3540C1a
Western blot analysis of immunized recombinant protein, using anti-DOCK7 monoclonal antibody.

Anti-DOCK7 Antibody - LS-C125473 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-DOCK7 Antibody - LS-C193957 from LifeSpan Bioscience

Prices $905.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DOCK7 Antibody - LS-C193958 from LifeSpan Bioscience

Prices $905.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DOCK7 Antibody (aa175-225) - LS-C290041 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOCK7 Antibody (aa2090-2140) - LS-C290042 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DOCK7 Antibody - LS-C307295 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

DOCK7 Antibody - NBP1-78748 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DOCK7 Antibody [NBP1-78748] - Whole cell lysate from HeLa (15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg), and Jurkat (J; 50 mcg) cells. Affinity purified rabbit anti-DOCK7 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. DOCK7 was also immunoprecipitated by rabbit anti-DOCK7 antibodyNBP1-78749 which recognizes a downstream epitope.

DOCK7 Antibody - NBP1-82894 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: DOCK7 Antibody [NBP1-82894] - Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.

DOCK7 Antibody - NBP1-78749 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DOCK7 Antibody [NBP1-78749] - Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Affinity purified rabbit anti-DOCK7 antibody used for IP at 6 mcg/mg lysate. DOCK7 was also immunoprecipitated by rabbit anti-DOCK7 antibody NBP1-78748, which recognizes an upstream epitope.

DOCK7 Polyclonal Antibody - bs-11825R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK7 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11825R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK7 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11825R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK7 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11825R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK7 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11825R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK7 Polyclonal Antibody, Cy3 Conjugated - bs-11825R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DOCK7 Polyclonal Antibody, Cy5 Conjugated - bs-11825R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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