| Gene Symbol |
SMARCA4
|
| Entrez Gene |
414274
|
| Alt Symbol |
BAF190A, BRG1
|
| Species |
Bovine
|
| Gene Type |
protein-coding
|
| Description |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
|
| Other Description |
ATP-dependent helicase SMARCA4|BRG1-associated factor 190A|SNF2-beta|SWI/SNF related transcriptional activator|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4|WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4|protein brahma homolog 1|transcription activator BRG1
|
| Swissprots |
A7Z019
|
| Accessions |
A7Z019 DAA28006 AY607778 AAT35581 BC153216 AAI53217 XM_010806783 XP_010805085 XM_010806784 XP_010805086 XM_010806785 XP_010805087 XM_010806786 XP_010805088 XM_010806787 XP_010805089 XM_010806788 XP_010805090 XM_010806789 XP_010805091 XM_010806790 XP_010805092 XM_010806791 XP_010805093 NM_001105614 NP_001099084
|
| Function |
Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-fOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chroma
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00549}.
|