| Gene Symbol |
JAM3
|
| Entrez Gene |
83700
|
| Alt Symbol |
JAM-2, JAM-3, JAM-C, JAMC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
junctional adhesion molecule 3
|
| Other Description |
junctional adhesion molecule C
|
| Swissprots |
Q96FL1 Q8WWL8 B3KWG9 Q9BX67
|
| Accessions |
CAF85939 CAF86920 CBX47566 CCA65346 EAW67817 EAW67818 EAW67819 EAW67820 Q9BX67 AF356518 AAK27221 AF448478 AAM20925 AJ344431 CAC69845 AJ416101 CAC94776 AK027435 AK074769 BAC11195 AK075309 BAC11538 AK125071 BAG54131 AK225666 AY358335 AAQ88701 BC010690 AAH10690 BC012147 AAH12147 BC057284 BC063031 W76344 NM_001205329 NP_001192258 NM_032801 NP_116190
|
| Function |
Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, desmosome. Secreted, extracellular space. Note=In epithelial cells, it is expressed at desmosomes but not at tight junctions. Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts.
|
| Tissue Specificity |
Highest expression in placenta, brain and kidney. Significant expression is detected on platelets. Expressed in intestinal mucosa cells. Expressed in the vascular endothelium. Found in serum (at protein level). Also detected in the synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis or ostearthritis (at protein level). {ECO:0000269|PubMed:11590146, ECO:0000269|PubMed:11944976, ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:20592283}.
|
| Top Pathways |
Tight junction, Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Epithelial cell signaling in Helicobacter pylori infection
|
![Western Blot: Junctional Adhesion Molecule C Overexpression Lysate (Adult Normal) [NBL1-12098] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Junctional Adhesion Molecule C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3958_Junctional%2520Adhesion%2520Molecule%2520C%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12098-img0002.jpg)