| Gene Symbol | Dbn1 |
|---|---|
| Entrez Gene | 81653 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | drebrin 1 |
| Other Description | developmentally-regulated brain protein|drebrin |
| Swissprots | O70205 Q07266 A5D6R1 |
| Accessions | EDL93980 EDL93981 EDL93982 EDL93983 Q07266 AB015042 BAA28746 AB514558 BAH89245 BC139847 AAI39848 FQ217148 X59267 CAA41957 XM_006253655 XP_006253717 XM_006253656 XP_006253718 XM_006253657 XP_006253719 XM_008771507 XP_008769729 NM_031024 NP_112286 |
| Function | Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS (By similarity). Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cell cortex {ECO:0000250}. Cell junction {ECO:0000250}. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (By similarity). {ECO:0000250}. |
| Tissue Specificity | Brain neurons. |
CompoZr® Knockout ZFN Kit - CKOZFN52770 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND52770 from Sigma-Aldrich
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DBN1 siRNA (Rat) - CRR2280 from Cohesion Biosciences
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DBN1 - MBS8221554 from MyBioSource
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shRNA set against Rat DBN1 (NM_031024.1) - SHH274753 from Creative biogene
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shRNA set against Rat Dbn1(NM_031024.1) - SHG222769 from Creative biogene
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DBN1 shRNA Plasmid (Rat) - CHR2280 from Cohesion Biosciences
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DBN1 miRNA 3'UTR clone - MiUTR1R-01380 from Creative biogene
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