| Gene Symbol |
TLR10
|
| Entrez Gene |
81793
|
| Alt Symbol |
CD290
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
toll-like receptor 10
|
| Other Description |
-
|
| Swissprots |
A8K7L1 Q32MI7 Q32MI8 Q6UXL3 B3Y668 D1CS22 Q9BXR5 D1CS21 Q5FWG4
|
| Accessions |
EAW92897 EAW92898 EAW92899 EAW92900 Q9BXR5 AB445680 BAG55077 AF296673 AAK26744 AK292026 BAF84715 AK313468 AW504309 AY358300 AAQ88667 BC089406 AAH89406 BC109111 AAI09112 BC109112 AAI09113 BP383038 DA213264 DA312129 DA643313 DB226380 DQ011502 AAY78477 DQ011503 AAY78478 DQ011504 AAY78479 DQ011505 AAY78480 DQ011506 AAY78481 DQ011507 AAY78482 DQ011508 AAY78483 DQ011509 AAY78484 DQ011510 AAY78485 DQ011511 AAY78486 DQ011512 AAY78487 DQ011513 AAY78488 DQ011514 AAY78489 DQ011515 AAY78490 DQ011516 AAY78491 XM_011513760 XP_011512062 XM_011513761 XP_011512063 XM_011513762 XP_011512064 NM_001017388 NP_001017388 NM_001195106 NP_001182035 NM_001195107 NP_001182036 NM_001195108 NP_001182037 NM_030956 NP_112218
|
| Function |
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
|
![Western Blot: TLR10 Overexpression Lysate (Adult Normal) [NBP2-08683] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TLR10.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3241_TLR10%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08683-img0001.jpg)
![Western Blot: Human TLR10 NF-kB/SEAP - (SEAPorter™) Stable Reporter Cell Line [NBP2-26273] - Analysis of TLR10 expression in the TLR10 reporter cell line using an HA antibody (20 ug total protein/lane). Legend: Cont: Control, NF-kB/SEAPorterTM HEK 293 cell line; TLR10: TLR10 reporter cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10758_Human-TLR10-NF-kB-SEAP---(SEAPorter(TM))-Stable-Reporter-Cell-Line-Western-Blot-NBP2-26273-img0010.jpg)
![Western Blot: Human TLR10 Stable Cell Line [NBP2-26265] - TLR10 expression in the TLR10 stable cell line using an HA antibody (20 ug total protein/lane). Legend. Vect: Vector control stable cell line; TLR10: TLR10 stable cell line.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10781_Human%2520TLR10%2520Stable%2520Cell%2520Line-Western%2520Blot-NBP2-26265-img0004.jpg)