| Gene Symbol |
Cacna2d3
|
| Entrez Gene |
306243
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, alpha2/delta subunit 3
|
| Other Description |
calcium channel, voltage dependent, alpha2/delta subunit 3|calcium channel, voltage-dependent, alpha 2/delta 3 subunit|voltage-dependent calcium channel subunit alpha-2/delta-3|voltage-gated calcium channel subunit alpha-2/delta-3
|
| Swissprots |
Q8CFG5
|
| Accessions |
EDL89015 EDL89016 Q8CFG5 AF486278 AAO14654 XM_008770993 XP_008769215 XM_008770994 XP_008769216 NM_175595 NP_783185
|
| Function |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
In heart, it is expressed in atrium but not in ventricle. {ECO:0000269|PubMed:12606261}.
|
| Top Pathways |
MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy
|