| Gene Symbol |
Vegfa
|
| Entrez Gene |
22339
|
| Alt Symbol |
Vegf, Vpf
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
vascular endothelial growth factor A
|
| Other Description |
vascular permeability factor
|
| Swissprots |
Q6WZL9 Q66S31 O70123 Q00731 Q6GT23
|
| Accessions |
BAC54913 EDL23467 Q00731 AK031905 AK131850 AW913188 AY120866 AAM55477 AY263146 AAP86647 AY707864 AAU11325 AY750956 AAU95484 AY750957 AAU95485 AY756068 AAV32504 BC022642 BC061468 AAH61468 BQ554097 BQ832724 BU920197 BY001490 CA321456 CK626177 EF028705 ABK27265 HQ712122 ADY05339 M95200 AAA40547 S37052 AAB22252 S38083 AAB22253 S38100 AAB22254 U50279 AAC05442 NM_001025250 NP_001020421 NM_001025257 NP_001020428 NM_001110266 NP_001103736 NM_001110267 NP_001103737 NM_001110268 NP_001103738 NM_001287056 NP_001273985 NM_009505 NP_033531 NM_001287057 NP_001273986 NM_001287058 NP_001273987
|
| Function |
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform VEGF-3: Cell membrane; Peripheral membrane protein. Note=Remains cell-surface associated unless released by heparin.
|
| Tissue Specificity |
In developing embryos, expressed mainly in the choroid plexus, paraventricular neuroepithelium, placenta and kidney glomeruli. Also found in bronchial epithelium, adrenal gland and in seminiferous tubules of testis. High expression of VEGF continues in kidney glomeruli and choroid plexus in adults.
|
| Top Pathways |
PI3K-Akt signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, VEGF signaling pathway, Focal adhesion
|