Gene Symbol | BRINP1 |
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Entrez Gene | 1620 |
Alt Symbol | DBC1, DBCCR1, FAM5A |
Species | Human |
Gene Type | protein-coding |
Description | bone morphogenetic protein/retinoic acid inducible neural-specific 1 |
Other Description | BMP/retinoic acid-inducible neural-specific protein 1|bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A))|bone morphogenic protein/retinoic acid inducible neural-specific 1|deleted in bladder cancer 1|deleted in bladder cancer chromosome region candidate 1|deleted in bladder cancer protein 1 |
Swissprots | Q8WU22 O60477 Q6P1A0 Q6IPV6 |
Accessions | EAW87455 EAW87456 O60477 AF027734 AAC39691 AK293501 BAG56986 AK293649 BAG57101 BC021560 AAH21560 BC065196 AAH65196 BC071702 AAH71702 Z41452 NM_014618 NP_055433 |
Function | Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway. {ECO:0000269|PubMed:11420708, ECO:0000269|PubMed:14712213, ECO:0000269|PubMed:16369496}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11420708}. |
Tissue Specificity | Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine. {ECO:0000269|PubMed:9545632}. |
DBC1 CRISPR/Cas9 KO Plasmid (h) - sc-408512 from Santa Cruz Biotechnology
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DBC1 HDR Plasmid (h) - sc-408512-HDR from Santa Cruz Biotechnology
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DBC1 Double Nickase Plasmid (h) - sc-408512-NIC from Santa Cruz Biotechnology
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DBC1 Double Nickase Plasmid (h2) - sc-408512-NIC-2 from Santa Cruz Biotechnology
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DBC1 CRISPR Activation Plasmid (h) - sc-408512-ACT from Santa Cruz Biotechnology
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DBC1 CRISPR Activation Plasmid (h2) - sc-408512-ACT-2 from Santa Cruz Biotechnology
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DBC1 Lentiviral Activation Particles (h) - sc-408512-LAC from Santa Cruz Biotechnology
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DBC1 Lentiviral Activation Particles (h2) - sc-408512-LAC-2 from Santa Cruz Biotechnology
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DBC1 siRNA (h) - sc-92672 from Santa Cruz Biotechnology
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DBC1 shRNA Plasmid (h) - sc-92672-SH from Santa Cruz Biotechnology
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DBC1 shRNA (h) Lentiviral Particles - sc-92672-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6942 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6942 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04489 from Sigma-Aldrich
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BRINP1 siRNA (Human) - CRH1141 from Cohesion Biosciences
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DBC1 RNAi - H00001620-R01 from Novus Biologicals
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BRINP1 - MBS8228453 from MyBioSource
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shRNA set against Human DBC1 (NM_014618.2) - SHH274685 from Creative biogene
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shRNA set against Human DBC1(NM_014618.2) - SHG222113 from Creative biogene
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BRINP1 shRNA Plasmid (Human) - CHH1141 from Cohesion Biosciences
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DBC1 miRNA 3'UTR clone - MiUTR1H-02674 from Creative biogene
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