| Gene Symbol |
EIF3B
|
| Entrez Gene |
8662
|
| Alt Symbol |
EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit B
|
| Other Description |
eIF-3-eta|eIF3 p110|eIF3 p116|eukaryotic translation initiation factor 3 subunit 9|eukaryotic translation initiation factor 3 subunit B|eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD)|eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa|hPrt1|prt1 homolog
|
| Swissprots |
A4D208 Q9UMF9 Q2NL77 P55884
|
| Accessions |
AAP21880 EAL23951 EAL23952 EAW87237 EAW87238 EAW87239 EAW87240 EAW87241 P55884 AB209381 BAD92618 AI888128 AK093807 AK126670 AK127885 AK300967 BAG62591 AK302058 BAG63448 BC001173 AAH01173 BC009986 AAH09986 BC110865 AAI10866 BG325094 BM556863 BQ015102 BQ045103 BQ070291 U62583 AAB42010 U78525 AAC99479 XM_011515599 XP_011513901 XM_011515600 XP_011513902 XM_011515601 XP_011513903 NM_001037283 NP_001032360 NM_003751 NP_003742
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000269|PubMed:9388245}.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}.
|
| Top Pathways |
RNA transport
|