TMEM67

Gene Symbol TMEM67
Entrez Gene 91147
Alt Symbol JBTS6, MECKELIN, MKS3, NPHP11, TNEM67
Species Human
Gene Type protein-coding
Description transmembrane protein 67
Other Description Meckelin|meckel syndrome type 3 protein
Swissprots G5E9H2 B3KRU5 Q3ZCX3 Q8IZ06 Q5HYA8 Q7Z5T8 B3KT47
Accessions EAW91701 EAW91702 EAW91703 Q5HYA8 AK026742 AK092244 BAG52507 AK094935 BAG52959 AK297676 BAG60037 AK308071 AK308735 BC017974 BC031220 BC032835 AAH32835 BC054338 BM310097 BX648768 CAI45999 DA928293 DC368894 JF432845 ADZ16062 XM_006716686 XP_006716749 XM_006716687 XP_006716750 XM_011517363 XP_011515665 XR_428387 XR_928360 XR_928361 XR_928362 NM_001142301 NP_001135773 NM_153704 NP_714915 NR_024522
Function Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). {ECO:0000250, ECO:0000269|PubMed:17185389, ECO:0000269|PubMed:19515853, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:19815549}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}.
Tissue Specificity Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord. {ECO:0000269|PubMed:16415887, ECO:0000269|PubMed:17185389}.

MKS3 (H-300) - sc-366751 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MKS3 (P-14) - sc-87298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Meckelin antibody - ab76786 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Meckelin antibody (ab76786) + HEK293 whole cell extract.

Anti-Meckelin antibody - ab97934 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Meckelin antibody (ab97934) at 1/1000 dilution + H1299 whole cell lysate at 30 µg

Anti-TMEM67 Antibody (C-Terminus) - LS-C144940 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TMEM67 Antibody (aa231-510) - LS-C186138 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. TMEM67 antibody diluted at 1:1000

Meckelin Antibody - NBP1-06590 from Novus Biologicals

Prices $299.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Meckelin Antibody [NBP1-06590] - Immunodetection of Meckelin (120kDa) in whole cell extracts of HEK293 cells.

Meckelin Antibody - NBP1-89628 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Meckelin Antibody [NBP1-89628] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.

Meckelin Antibody - NBP1-32896 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TMEM67 antibody produced in rabbit - SAB2700431 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TMEM67: <B>Cat. No. SAB2700431</B>: Western Blot analysis of TMEM67 in extracts from <B>Lanes</B><BR/>A. H1299 using <B>Cat. No. SAB2700431</B> at a 1:1000 dilution.

Anti-TMEM67 antibody produced in rabbit - HPA039940 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-TMEM67: <B>Cat. No. HPA039940</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

TMEM67 antibody - 70R-20877 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

TMEM67 antibody (OAGA00833) - OAGA00833 from Aviva Systems Biology

Prices $340.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Meckelin antibody - orb13160 from Biorbyt

Prices $323.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal
Western Blot analysis of mouse spinal cord using Meckelin antibody

Meckelin isoform 1 antibody - 70R-13348 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Meckelin antibody - 13975-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human hepatocirrhosis using 13975-1-AP(TMEM67 antibody) at dilution of 1:50 (under 40x lens)

Meckelin antibody - AP55072SU-N from Acris Antibodies

Prices $460.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of kideny tissue sections with AP55072SU-N

Anti-Meckelin - BPA1075 from ARP American Research Products

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MKS3 antibody - 13975-1-AP from Proteintech Group

Prices $279.00
Sizes con: 26 μg/150μl
Host Rabbit
Clonality Polyclonal
IF result from Dr. Corbit, Kevin. anti-MKS3(13975-1-AP) marks the proximal transition zone and basal body of Human hTERT-RPE1 cells and Mouse embryonic fibroblasts.

meckelin isoform 1 antibody - 22668 from Signalway Antibody

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: H1299 7.5% SDS PAGE Primary antibody diluted at 1: 1000

Meckelin Antibody - E80903-7 from Enogene

Prices $225.00
Sizes 100ul 0.25mg/ml

TMEM67 Polyclonal Antibody - PA5-22095 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of meckelin isoform 1 using 30µg of H1299 lysate. Samples were loaded onto a 7.5% SDS-PAGE gel and probed with a meckelin isoform 1 polyclonal antibody (Product # PA5-22095) at a dilution of 1:1000.

Meckelin, Polyclonal Antibody - MBS857207 from MyBioSource

Prices $290.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Meckelin isoform 1, Polyclonal Antibody - MBS837267 from MyBioSource

Prices $515.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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