Gene Symbol | LAMA4 |
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Entrez Gene | 3910 |
Alt Symbol | CMD1JJ, LAMA3, LAMA4*-1 |
Species | Human |
Gene Type | protein-coding |
Description | laminin, alpha 4 |
Other Description | laminin alpha 4 chain|laminin subunit alpha-4 |
Swissprots | Q5SZG8 Q4LE44 Q9UJN9 Q9UE18 Q9BTB8 Q15335 Q14731 Q14735 Q16363 |
Accessions | CAA74636 EAW48266 EAW48267 EAW48268 EAW48269 EAW48270 Q16363 AB210027 BAE06109 AJ710266 AK027151 AK304401 BAH14174 BC004241 AAH04241 BC026237 AAH26237 BC066552 AAH66552 BM014298 BM662226 BP234809 BT006690 AAP35336 BX648467 CR407622 CAG28550 DB271101 JF432726 ADZ15943 S78569 AAB34635 U77706 AAB36540 X70904 CAA50261 X76939 CAA54258 X91171 CAA62596 XM_005266983 XP_005267040 XM_005266984 XP_005267041 XM_011535821 XP_011534123 NM_001105206 NP_001098676 NM_001105207 NP_001098677 NM_001105208 NP_001098678 NM_001105209 NP_001098679 NM_002290 NP_002281 |
Function | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
Tissue Specificity | In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn tissues is observed in certain mesenchymal cells in tissues such as smooth muscle and dermis. |
Top Pathways | Focal adhesion, ECM-receptor interaction, Small cell lung cancer, Amoebiasis, Toxoplasmosis |
Laminin α-4 CRISPR/Cas9 KO Plasmid (h) - sc-401801 from Santa Cruz Biotechnology
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Laminin α-4 HDR Plasmid (h) - sc-401801-HDR from Santa Cruz Biotechnology
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Laminin α-4 Double Nickase Plasmid (h) - sc-401801-NIC from Santa Cruz Biotechnology
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Laminin α-4 Double Nickase Plasmid (h2) - sc-401801-NIC-2 from Santa Cruz Biotechnology
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Laminin α-4 CRISPR Activation Plasmid (h) - sc-401801-ACT from Santa Cruz Biotechnology
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Laminin α-4 CRISPR Activation Plasmid (h2) - sc-401801-ACT-2 from Santa Cruz Biotechnology
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Laminin α-4 Lentiviral Activation Particles (h) - sc-401801-LAC from Santa Cruz Biotechnology
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Laminin α-4 Lentiviral Activation Particles (h2) - sc-401801-LAC-2 from Santa Cruz Biotechnology
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Laminin α-4 siRNA (h) - sc-43147 from Santa Cruz Biotechnology
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Laminin α-4 shRNA Plasmid (h) - sc-43147-SH from Santa Cruz Biotechnology
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Laminin α-4 shRNA (h) Lentiviral Particles - sc-43147-V from Santa Cruz Biotechnology
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Laminin alpha 4 RNAi - H00003910-R01 from Novus Biologicals
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Laminin alpha 4 RNAi - H00003910-R02 from Novus Biologicals
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Laminin alpha 4 RNAi - H00003910-R05 from Novus Biologicals
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Laminin alpha 4 RNAi - H00003910-R03 from Novus Biologicals
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Laminin alpha 4 RNAi - H00003910-R04 from Novus Biologicals
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MISSION® esiRNA - EHU152011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11529 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11529 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04801 from Sigma-Aldrich
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LAMA4 siRNA (Human) - CRH2649 from Cohesion Biosciences
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Human LAMA4 siRNA - orb263151 from Biorbyt
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LAMA4 shRNA Plasmid (Human) - CHH2649 from Cohesion Biosciences
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LAMA4 miRNA 3'UTR clone - MiUTR3H-03150 from Creative biogene
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LAMA4 miRNA 3'UTR clone - MiUTR3H-03151 from Creative biogene
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