CTH

Gene Symbol	CTH
Entrez Gene	1491
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cystathionine gamma-lyase
Other Description	cystathionase (cystathionine gamma-lyase)|cysteine desulfhydrase|cysteine-protein sulfhydrase|gamma-cystathionase|homoserine deaminase|homoserine dehydratase
Swissprots	Q53Y79 E9PDV0 P32929 Q9H4W7 Q53FB3 Q9H4W8 B4E1R2
Accessions	EAX06450 EAX06451 P32929 AK223376 BAD97096 AK303946 BAG64874 AK310269 BC015807 AAH15807 BT006882 AAP35528 DB466459 EU832313 ACE87570 EU832398 ACE86883 S52028 AAB24699 S52784 AAB24700 XM_005270509 XP_005270566 XM_011540787 XP_011539089 NM_001190463 NP_001177392 NM_001902 NP_001893 NM_153742 NP_714964
Function	Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. {ECO:0000269|PubMed:19019829, ECO:0000269|PubMed:19261609, ECO:0000269|PubMed:22169477}.
Subcellular Location	Cytoplasm.
Top Pathways	Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Selenocompound metabolism, Biosynthesis of amino acids

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CTH / Cystathionase ELISA Kit (Sandwich ELISA) - LS-F5701 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Rat CTH / Cystathionase ELISA Kit (Sandwich ELISA) - LS-F7695 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.312-20 ng/ml

Human CTH / Cystathionase ELISA Kit (Sandwich ELISA) - LS-F11123 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.312-20 ng/ml

Cystathionine Gamma Lyase (CSE), Human, ELISA Kit - SEB538Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.63ng/mL Range 1.56-100ng/mL

Cystathionine gamma-lyase (CTH), Human, ELISA Kit - CSB-EL006160HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cystathionine gamma-lyase, CTH, Human, ELISA Kit - E1538h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

CTH (Human) Matched Antibody Pair - H00001491-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CTH (Human) Matched Antibody Pair - H00001491-AP12 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CTH (Human) Matched Antibody Pair - H00001491-AP13 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CTH (Human) Matched Antibody Pair - H00001491-AP52 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

CTH (Human) Matched Antibody Pair - H00001491-AP61 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

cystathionase (cystathionine gamma-lyase) , ELISA Kit - MBS939804 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human CTH is typically less than 7.8 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 31.2 pg/ml -2000 pg/ml.

ELISA Kit for Cystathionine Gamma Lyase (CSE) - SEB538Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Cystathionine Gamma Lyase (CSE) - SEB538Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Cystathionine gamma-lyase(CTH) ELISA kit - CSB-EL006160HU from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml Range 31.2 pg/ml-2000 pg/ml

ELISA Kit for Cystathionine Gamma Lyase (CSE) - SEB538Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.121ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse CTH / Cystathionase ELISA Kit (Custom ELISA) - LS-F17947 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Pig CTH / Cystathionase ELISA Kit (Custom ELISA) - LS-F17948 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Bovine CTH / Cystathionase ELISA Kit (Custom ELISA) - LS-F17946 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Rat CTH / Cystathionase ELISA Kit (Custom ELISA) - LS-F17949 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human Cystathionine gamma-lyase ELISA Kit - abx251107 from Abbexa Category ELISA Kit Range 0.78 ng/ml - 50 ng/ml

Rat CTH / Cystathionase ELISA Kit (Competitive EIA) - LS-F27927 from LifeSpan Bioscience Category ELISA Kit Prices $870.00 Sizes 1 plate Sensitivity 0.1 ng/ml Range 0.312-20 ng/ml

Human Cystathionine gamma-lyase (CTH) ELISA Kit - EKC33350 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.8 pg/ml Range 31.2 pg/ml-2000 pg/ml

Human Cystathionine gamma-lyase ELISA Kit - EKE52783 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 0.23 ng/mL Range 0.78-50 ng/mL

CTH - EKH3598 from Nordic BioSite Sensitivity 0.469ng/ml Range 0.78-50ng/ml

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