| Gene Symbol | Zfand5 |
|---|---|
| Entrez Gene | 22682 |
| Alt Symbol | 2310057A04Rik, 5830475F03Rik, AA415485, Za20d2, Zfp216 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | zinc finger, AN1-type domain 5 |
| Other Description | AN1-type zinc finger protein 5|zinc finger A20 domain-containing protein 2|zinc finger protein 216|zinc finger, A20 domain containing 2 |
| Swissprots | Q3B7K8 O88878 |
| Accessions | EDL41583 O88878 AF062071 AAC42600 AK009947 AK018054 AK039663 AK046445 AK076397 BAC36321 AK131911 AK185148 AK186976 AK211340 AK216435 AK218278 BC048232 BC061693 BC080270 BC107566 AAI07567 BC119124 AAI19125 BC119126 AAI19127 EF437362 L37047 XM_006527058 XP_006527121 NM_009551 NP_033577 |
| Function | Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4- induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation. {ECO:0000269|PubMed:16194934, ECO:0000269|PubMed:16424905}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Expressed in brain, muscle, eye, and heart, lower expression in lung, kidney, and spleen, and very low expression in liver. Expressed in myoblast C2C12 cells (at protein level). {ECO:0000269|PubMed:14754897, ECO:0000269|PubMed:9758550}. |