UPF1

Gene Symbol UPF1
Entrez Gene 5976
Alt Symbol HUPF1, NORF1, RENT1, pNORF1, smg-2
Species Human
Gene Type protein-coding
Description UPF1 regulator of nonsense transcripts homolog (yeast)
Other Description ATP-dependent helicase RENT1|delta helicase|nonsense mRNA reducing factor 1|regulator of nonsense transcripts 1|smg-2 homolog, nonsense mediated mRNA decay factor|up-frameshift mutation 1 homolog|up-frameshift suppressor 1 homolog|yeast Upf1p homolog
Swissprots Q86Z25 Q92900 O00239 Q92842 O43343
Accessions AAB94785 AAC09016 AIA19311 AIA19312 AIA19313 AIA19314 AIA19315 AIA19316 AIA19317 AIA19318 AIA19319 AIA19320 AIA19321 AIA19322 AIA19323 AIA19324 AIA19325 AIA19326 AIA19327 AIA19328 EAW84738 EAW84739 EAW84740 EAW84741 EAW84742 Q92900 AF074016 AAC26788 AK125797 BAC86297 AK128727 BAG54717 BC034291 BC039817 AAH39817 BE243084 BM969672 BQ950083 BX331580 BX364728 CB960545 D86988 BAA19664 U59323 AAC51140 U65533 AAC50771 NM_001297549 NP_001284478 NM_002911 NP_002902
Function RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1- eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more nucleotides downstream from the termination codon) through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Phosphorylated UPF1 is recognized by EST1B/SMG5, SMG6 and SMG7 which are thought to provide a link to the mRNA degradation machinery involving exonucleolytic and endonucleolytic pathways, and to serve as adapters to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosph
Subcellular Location Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
Tissue Specificity Ubiquitous.
Top Pathways RNA transport, mRNA surveillance pathway

Rent1 CRISPR/Cas9 KO Plasmid (h) - sc-402462 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 HDR Plasmid (h) - sc-402462-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 Double Nickase Plasmid (h) - sc-402462-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 Double Nickase Plasmid (h2) - sc-402462-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 CRISPR Activation Plasmid (h) - sc-402462-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 CRISPR Activation Plasmid (h2) - sc-402462-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 Lentiviral Activation Particles (h) - sc-402462-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 Lentiviral Activation Particles (h2) - sc-402462-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Rent1 siRNA (h) - sc-38223 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent1 shRNA Plasmid (h) - sc-38223-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent1 shRNA (h) Lentiviral Particles - sc-38223-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent1 siRNA (h2) - sc-108072 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent1 shRNA Plasmid (h2) - sc-108072-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Rent1 shRNA (h2) Lentiviral Particles - sc-108072-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU035531 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22516 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22516 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UPF1 siRNA (Human) - CRH4044 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RENT1/UPF1/hUPF1 RNAi - H00005976-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

UPF1 - MBS8207797 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UPF1 (NM_002911.3) - SHH440733 from Creative biogene

Category siRNA
Species Reactivities Human

Human UPF1 siRNA - orb264546 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UPF1 shRNA Plasmid (Human) - CHH4044 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UPF1 miRNA 3'UTR clone - MiUTR1H-11025 from Creative biogene

Species Reactivities Human
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