AKR1D1

Gene Symbol AKR1D1
Entrez Gene 6718
Alt Symbol 3o5bred, CBAS2, SRD5B1
Species Human
Gene Type protein-coding
Description aldo-keto reductase family 1, member D1
Other Description 3-oxo-5-beta-steroid 4-dehydrogenase|delta 4-3-ketosteroid-5-beta-reductase|delta(4)-3-ketosteroid 5-beta-reductase|delta(4)-3-oxosteroid 5-beta-reductase|steroid-5-beta-reductase, beta polypeptide 1 (3-oxo-5 beta-steroid delta 4-dehydrogenase beta 1)
Swissprots P51857 A1L4P6 B4DPN8 B4DPN3 A8K060
Accessions AAG39381 EAL24049 EAW83881 EAW83882 P51857 AK058142 BAB71682 AK289425 BAF82114 AK298421 BAG60645 AK298428 BAG60650 BC130625 AAI30626 BC130627 AAI30628 BG210362 CB111926 FM160741 CAQ55951 FM160742 CAQ55952 FM160743 CAQ55953 HQ258384 ADR83138 Z28339 CAA82193 NM_001190906 NP_001177835 NM_001190907 NP_001177836 NM_005989 NP_005980
Function Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates. {ECO:0000269|PubMed:11342103}.
Subcellular Location Cytoplasm.
Tissue Specificity Highly expressed in liver. Expressed in testis and weakly in colon. {ECO:0000269|PubMed:11342103}.
Top Pathways Primary bile acid biosynthesis, Steroid hormone biosynthesis

AKR1D1 CRISPR/Cas9 KO Plasmid (h) - sc-404897 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 HDR Plasmid (h) - sc-404897-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 Double Nickase Plasmid (h) - sc-404897-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 Double Nickase Plasmid (h2) - sc-404897-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 CRISPR Activation Plasmid (h) - sc-404897-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 CRISPR Activation Plasmid (h2) - sc-404897-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 Lentiviral Activation Particles (h) - sc-404897-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 Lentiviral Activation Particles (h2) - sc-404897-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AKR1D1 siRNA (h) - sc-61964 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AKR1D1 shRNA Plasmid (h) - sc-61964-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AKR1D1 shRNA (h) Lentiviral Particles - sc-61964-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AKR1D1 RNAi - H00006718-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: AKR1D1 RNAi [H00006718-R01V] - Analysis of AKR1D1 over-expressed 293 cell line. Lane 2 cotransfected with AKR1D1 Validated Chimera RNAi Lane 1 non-transfected control. Blot probed with H00006718-M03. GAPDH (36.1 kDa) used as loading control.

AKR1D1 RNAi - H00006718-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU098681 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2318 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2318 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10280 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr10280

AKR1D1 siRNA (Human) - CRH4587 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AKR1D1 - MBS8215251 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human AKR1D1 (NM_005989.3) - SHH234602 from Creative biogene

Category siRNA
Species Reactivities Human

AKR1D1 shRNA Plasmid (Human) - CHH4587 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AKR1D1 miRNA 3'UTR clone - MiUTR3H-07062 from Creative biogene

Species Reactivities Human
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