Gene Symbol | FGF19 |
---|---|
Entrez Gene | 9965 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | fibroblast growth factor 19 |
Other Description | FGF-19 |
Swissprots | O95750 |
Accessions | EAW74751 O95750 AB018122 BAA75500 AF110400 AAD45973 AY358302 AAQ88669 BC017664 AAH17664 BT006729 AAP35375 JF432499 ADZ15716 NM_005117 NP_005108 |
Function | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. {ECO:0000269|PubMed:12815072, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:19085950}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed in fetal brain, cartilage, retina, and adult gall bladder. {ECO:0000269|PubMed:10525310}. |
Top Pathways | Melanoma, MAPK signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton |
Active human FGF19 full length protein - ab108946 from Abcam
|
||||||||||
Active human FGF19 full length protein - ab200246 from Abcam
|
||||||||||
FGF19 peptide - ab93789 from Abcam
|
||||||||||
Human FGF19 full length protein - ab55524 from Abcam
|
||||||||||
Human FGF19 full length protein - ab73213 from Abcam
|
||||||||||
Human FGF19 protein fragment - ab50132 from Abcam
|
||||||||||
Human FGF19 protein fragment - ab185824 from Abcam
|
||||||||||
FGF19 Antibody Blocking Peptide - LS-E5695 from LifeSpan Bioscience
|
||||||||||
FGF19 Antibody Blocking Peptide - LS-E23243 from LifeSpan Bioscience
|
||||||||||
Recombinant Human FGF-19 Protein - NBP2-35013 from Novus Biologicals
|
||||||||||
FGF-19 Recombinant Protein - H00009965-P01 from Novus Biologicals
|
||||||||||
FGF-19 Recombinant Protein - H00009965-P02 from Novus Biologicals
|
||||||||||
FGF-19 Recombinant Protein - P4089 from Novus Biologicals
|
||||||||||
Recombinant Human FGF-19 Protein - NBP1-99420 from Novus Biologicals
|
||||||||||
FGF-19 Protein - NBP1-99661 from Novus Biologicals
|
||||||||||
FGF19-Antibody-C-term-Blocking-Peptide - BP18231b from Abgent, a WuXi AppTec company
|
||||||||||
FGF19 recombinant protein - GTX65308 from GeneTex
|
||||||||||
FGF19 Recombinant Protein (Active) - GTX48324-PRO from GeneTex
|
||||||||||
Recombinant Human FGF-19 - 969-FG-025 from R&D Systems
|
||||||||||
Recombinant Human FGF-19, CF - 969-FG-025/CF from R&D Systems
|
||||||||||
Recombinant human Fibroblast growth factor 19 protein (OPCA00646) - OPCA00646 from Aviva Systems Biology
|
||||||||||
FGF 19 Protein (OPPA00544) - OPPA00544 from Aviva Systems Biology
|
||||||||||
FGF 19 Protein (OPPA01883) - OPPA01883 from Aviva Systems Biology
|
||||||||||
Human FGF-19 protein - orb245287 from Biorbyt
|
||||||||||
Human FGF 19 protein - orb138859 from Biorbyt
|