| Gene Symbol |
TRPA1
|
| Entrez Gene |
8989
|
| Alt Symbol |
ANKTM1, FEPS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily A, member 1
|
| Other Description |
ankyrin-like with transmembrane domains 1|transformation-sensitive protein p120|transient receptor potential cation channel subfamily A member 1
|
| Swissprots |
A6NIN6 O75762
|
| Accessions |
EAW86986 O75762 AK307942 BC148423 AAI48424 BC153003 AAI53004 Y10601 CAA71610 XM_011517624 XP_011515926 XM_011517625 XP_011515927 NM_007332 NP_015628
|
| Function |
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed at very low level. Expressed at very low level in human fibroblasts and at a moderate level in liposarcoma cells. {ECO:0000269|PubMed:10066796}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|